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    Comparison of serum androgens and endometrial thickness in obese and non-obese postmenopausal women [Obez ve obez olmayan postmenopozal hastalarda serum androjen seviyeleri ve endometrial kali{dotless}nli{dotless}gn karşi{dotless}laşti{dotless}nlmasi{dotless}]
    (2010) Arikan I.I.; Barut A.; Arikan D.; Harma M.; Harma M.I.; Bozkurt S.
    Objective: In this study, we investigated whether serum androgen levels and endometrial thickness differed in obese and non-obese women. Material and Methods: Thirtytwo non-obese (BMI <30) and 48 obese (BMI ? 30) women were enrolled. Blood samples were analyzed for testosterone, free testosterone, androstenedione, DHEAS, and SHBG, and transvaginal ultrasonography was performed. Results: Obese women had significantly higher free testosterone and endometrial thickness and significantly lower SHBG. Eight of 17 women with endometrial thickness >5 mm had significant pathology. Conclusion: These results suggest that obesity may be a risk factor for endometrial carcinoma and other pathologies in post-menopausal women through an action on androgen concentrations.
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    Differences in the cytological features of atypical adenomatous hyperplasia and low-grade prostatic adenocarcinoma
    (2010) Midi A.; Tecimer T.; Bozkurt S.; Özkan N.
    Objective: The aim of this study was to review the histological features and to define parameters distinguishing atypical adenomatous hyperplasia from prostatic adenocarcinoma grade 1 and 2. We evaluated 14 parameters related with cytological properties. Material and Method: We found 11 atypical adenomatous hyperplasia (22 foci) and 15 prostatic adenocarcinoma grade 1 and 2 (22 foci) lesions in 105 radical prostatectomy specimens. Basal cell-specific keratin (34ßE12) was applied and based on the fact that prostatic adenocarcinoma grade 1 and 2 lesions do not have basal cells we grouped the lesions as atypical adenomatous hyperplasia and prostatic adenocarcinoma grade 1 and 2. Results: Statistically significant differences were found between atypical adenomatous hyperplasia and prostatic adenocarcinoma grade 1 and 2 lesions for some parameters including the largest nuclear diameter, nuclear location, 1-2 µm nucleolus, > 2 µm nucleolus, and nuclei containing multiple nucleoli. We found similar properties between the two lesions for the following parameters: irregularity of nuclear membrane, median diameter of the nucleolus, chromatin pattern, pynotic nucleus, nuclear pleomorphism, < 1 µm nucleolus, nucleolar margination, and the ratio of nucleus to cytoplasm and the appearance of cytoplasm in the secretory cells. Conclusion: Evaluation of the overall histomorphological criteria is important in the differentiation of atypical adenomatous hyperplasia and prostatic adenocarcinoma grade 1 and 2 lesions.
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    Laparoscopic surgery of interstitial (cornual) pregnancy, a case report [İntertisyel (kornual) gebeligin laparoskopik tedavisi, vaka sunumu]
    (2010) Günenç Z.; Bingöl B.; Çelik A.; Bozkurt S.; Özekici U.
    we report a successful laparoscopic management of an interstitial pregnancy of a 24- year-old single woman, treated by cornuostomy. The patient was first managed with methotrexate treatment. After the 2.methotrexate administration, the patient suffered from low abdominal pain, and intraabdominal bleeding signs were reported by transvaginal ultrasonograpy. The hemoglobin level was decreased from 12.8 gr/dl to 11.8 gr/dl and the beta hCG level was increased from 8,314 mIU/l to 11,541 mIU/l. The laparoscopic approach to interstitial pregnancy was presented and other management strategies such as medical treatment and laparotomy have been reviewed.