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Yayın Aloe Barbadensis'in reproduktif sisteme etkisinin araştırılması(İstanbul Üniversitesi Veteriner Fakültesi Dergisi, 2008) Kosif, Rengin; Birincioğlu, SerapBir Aloe Vera tipi olan Aloe Barbadensis’in doğum sürecindeki ratların reprodüktif sistemine olan etkisi araştırıldı. Bunun için Aloe Barbadensis’in tedavi amaçlı kullanılmayan ticari bir formu olan Aloe Vera jel kullanıldı. Bir kontrol ve 2 deney grubu olmak üzere, 3 grup Wistar Albino hiç doğum yapmamış dişi ratlar üzerinde çalışıldı. Grup I’e günde 25 mg (140 mg/kg ) Aloe Barbadensis oral yolla ve gavaj uygulanarak verildi. Aloe Barbadensis 500 mg soya yağı içeren kapsüller içinde bulunmaktaydı, o nedenle grup II’ye her gün 500 mg soya yağı verildi. Grup III ise kontrol grubuydu. 3 grup da normal yem ve su ile beslendi. Doğum gerçekleşene kadar 20 gün boyunca hergün madde uygulandı. 21. gün ratlar anestezi altında açıldı. Reprodüktif sisteme ait organların doku örnekleri rutin histolojik prosedürü takiben ışık mikroskobunda incelendi. Aloe Barbadensis verilen grupta uterus dokusu hiperemik görünümde damarlar belirgin ve dilateydi. Lamina propria’dan myometriuma kadar tüm katmanlarda nötrofil lökosit infiltrasyonu belirlendi. Endometriumda bezler kistik dilate görünümde, damarlanmada artma ve endometrium lümen epitelyumunda hipertrofi mevcuttu. Endometriumun epitelyum hücrelerinin Aloe Barbadensis verilen grupta yer yer yüksekliklerinin artmış olduğu, nucleus’larının büyüdüğü, tek katlı epitelyumun yer yer çok katlı hale geldiği gözlendi. Hiperplaziden çok hipertrofi belirgindi. Aloe Barbadensis verilen grupta ovaryum dokusunun damarlı ve hiperemik hali dikkat çekiciydi. Ovaryumlardaki folliküller incelendiğinde primer follikül sayısında azalma, sekonder follikül çapında küçülme ve sayısında artış meydana geldi. Gebelik süresince uygulanan Aloe Barbadensis fetal ölüme, gelişme geriliğine, abortusa ya da anomaliye sebep olmadı. Histolojik değişiklikler bize uterusta Aloe Barbadensis’in angiogenesis etkisini ve östrojen benzeri etkisini, ovaryumda ise FSH benzeri etkisini işaret etmektedir. Bu etki 140 mg/kg dozda fetusa zarar vermemiştir.Yayın Investigation of the effects of Aloe barbadensis on rat ovaries: a preliminary study(Mary Ann Liebert, Inc. and Korean Society of Food Science and Nutrition, 2009) Kosif, RenginEffects of Aloe barbadensis, a type of Aloe vera, on ovaries were investigated during pregnancy. A. vera gel, a commercial and nontherapeutic form of A. barbadensis, was used for this purpose. Three groups (one control and two test groups) of female Wistar albino rats with no prior births were studied. Group I was administered 25?mg (140?mg/kg) of A. barbadensis/day both orally and through gavage. A. barbadensis was contained in capsules with 500?mg of soybean oil; therefore Group II was administered 500?mg of soybean oil. Group III was the control group. All three groups were given normal food and water ad libitum. The substance had been administered for 20 days until birth. Ovaries were examined histologically. Vascular increase and the hyperemic form of ovary in the group administered A. barbadensis were notable. Decrease in primary follicle numbers, increase in secondary follicle numbers, and diminishment of secondary follicle diameters occurred in ovaries. The histological changes imply an angiogenesis effect of A. barbadensis and an effect like that of follicle-stimulating hormone in ovaries.Yayın Microscopic examination of placenta of rats prenatally exposed to aloe barbadensis: a preliminary study(Revista Chilena de Anatomía, 2008) Kosif, Rengin; Öztekin, AynureAloe barbadensis is the most widely used both commercially and therapeutic properties. It has been used for an array of ailments since ancient times as a medicinal plant. There are more than 360 different species of Aloe. Its products have been used in health foods for medical and preservative purposes. The objective of this study was to search the effects of Aloe barbadensis on the rat's placenta. Gel form of Aloe barbadensis is used in the study. It is commercial, preserved but otherwise untreated form of Aloe Barbadensis gel capsul. Female Wistar Albino rats were divided into three groups. Placenta specimens from each groups were processed for the microscopic examination. Trophoblastic giant cells and spongiotrophoblasts were decreased in number after Aloe barbadensis: trophoblastic giant cells which showed degenerative changes. The nuclei of these giant cells were going degeneration characterized by pyknosis and bizarrely shaped. Extracellular matrix production around the cells was increased, thicker and more irregular basal membrane like formation around the cells. Decreased and ab normal vessel formation in labyrinth área was clear and reduced functional capacity of the trophoblastic barier. The study shows that, in the presence of Aloe barbadensis, relevant alterations associated with a possible compensatory adjustment to maintain adequate metabolic exchange take place in the structure of placenta. Our results also demonstrated that the exposure to Aloe barbadensis during pregnancy not led to fetal growth retardation, fetal death, abortion or teratogenic effect.Yayın Possible healing effects of aloe barbadensis on nephrotoxicity ınduced by soybean oil in rats(Erciyes Üniversitesi Tıp Fakültesi, 2011) Kosif, Rengin; Ok, ElvanPurpose: This study aimed to analyze the effects of Aloe barbadensis on kidney. Material and Methods: Eighteen Wistar Albino female rats were used for the experiment. They were divided into 3 groups. Biopsy materials were taken from the right kidneys of the rats and were analyzed under the light microscope. Results: Biopsy materials, which were taken from the kidneys of the control subjects, revealed normal structural features of renal cortex and medulla. No distinctive difference was found in the Malpighi corpuscles in the group receiving Aloe Barbadensis. However, various degrees of vacuolization in the proximal tubules, and the complete loss of structural characteristics of proximal tubules were observed. Vacuolization was rarely seen in distal tubules. Congestion was clear in the medulla. In the third group receiving only soybean oil, a distinctive congestion was observed in all glomerulus and in the medulla. The detected pathologic changes were more common and severe in the third experiment group that received only soybean oil. Congestion in glomerulus was mostly observed in this group. Conclusion: These results lead us to consider that Aloe barbadensis plays a healing role against the toxic effects of soybean oil on the kidney.Yayın Sıçanlarda soya yağı ile oluşturulan böbrek hasarı üzerine Aloe Barbadensis’in iyileştirici etkileri(Erciyes Üniversitesi, 2011) Kosif, Rengin; Aktaş, Ranan Gülhan; Ok, ElvanPurpose: This study aimed to analyze the effects of Aloe barbadensis on kidney. Material and Methods: Eighteen Wistar Albino female rats were used for the experiment. They were divided into 3 groups. Biopsy materials were taken from the right kidneys of the rats and were analyzed under the light microscope. Results: Biopsy materials, which were taken from the kidneys of the control subjects, revealed normal structural features of renal cortex and medulla. No distinctive difference was found in the Malpighi corpuscles in the group receiving Aloe Barbadensis. However, various degrees of vacuolization in the proximal tubules, and the complete loss of structural characteristics of proximal tubules were observed. Vacuolization was rarely seen in distal tubules. Congestion was clear in the medulla. In the third group receiving only soybean oil, a distinctive congestion was observed in all glomerulus and in the medulla. The detected pathologic changes were more common and severe in the third experiment group that received only soybean oil. Congestion in glomerulus was mostly observed in this group. Conclusion: These results lead us to consider that Aloe barbadensis plays a healing role against the toxic effects of soybean oil on the kidney.
