Aloe Barbadensis'in reproduktif sisteme etkisinin araştırılması
Küçük Resim Yok
Tarih
2008
Yazarlar
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
İstanbul Üniversitesi Veteriner Fakültesi Dergisi
Erişim Hakkı
CC0 1.0 Universal
info:eu-repo/semantics/openAccess
info:eu-repo/semantics/openAccess
Özet
Bir Aloe Vera tipi olan Aloe Barbadensis’in doğum sürecindeki ratların reprodüktif sistemine olan etkisi araştırıldı. Bunun için Aloe Barbadensis’in tedavi amaçlı kullanılmayan ticari bir formu olan Aloe Vera jel kullanıldı. Bir kontrol ve 2 deney grubu olmak üzere, 3 grup Wistar Albino hiç doğum yapmamış dişi ratlar üzerinde çalışıldı. Grup I’e günde 25 mg (140 mg/kg ) Aloe Barbadensis oral yolla ve gavaj uygulanarak verildi. Aloe Barbadensis 500 mg soya yağı içeren kapsüller içinde bulunmaktaydı, o nedenle grup II’ye her gün 500 mg soya yağı verildi. Grup III ise kontrol grubuydu. 3 grup da normal yem ve su ile beslendi. Doğum gerçekleşene kadar 20 gün boyunca hergün madde uygulandı. 21. gün ratlar anestezi altında açıldı. Reprodüktif sisteme ait organların doku örnekleri rutin histolojik prosedürü takiben ışık mikroskobunda incelendi. Aloe Barbadensis verilen grupta uterus dokusu hiperemik görünümde damarlar belirgin ve dilateydi. Lamina propria’dan myometriuma kadar tüm katmanlarda nötrofil lökosit infiltrasyonu belirlendi. Endometriumda bezler kistik dilate görünümde, damarlanmada artma ve endometrium lümen epitelyumunda hipertrofi mevcuttu. Endometriumun epitelyum hücrelerinin Aloe Barbadensis verilen grupta yer yer yüksekliklerinin artmış olduğu, nucleus’larının büyüdüğü, tek katlı epitelyumun yer yer çok katlı hale geldiği gözlendi. Hiperplaziden çok hipertrofi belirgindi. Aloe Barbadensis verilen grupta ovaryum dokusunun damarlı ve hiperemik hali dikkat çekiciydi. Ovaryumlardaki folliküller incelendiğinde primer follikül sayısında azalma, sekonder follikül çapında küçülme ve sayısında artış meydana geldi. Gebelik süresince uygulanan Aloe Barbadensis fetal ölüme, gelişme geriliğine, abortusa ya da anomaliye sebep olmadı. Histolojik değişiklikler bize uterusta Aloe Barbadensis’in angiogenesis etkisini ve östrojen benzeri etkisini, ovaryumda ise FSH benzeri etkisini işaret etmektedir. Bu etki 140 mg/kg dozda fetusa zarar vermemiştir.
Effects of Aloe Barbadensis, a type of Aloe Vera, on reproductive system were investigated during pregnancy. Aloe Vera gel, a commercial and nontherapeutic form of Aloe Barbadensis, was used for this purpose. 3 groups – 1 control and 2 test groups – of female Wistar Albino rats with no birth before were studied. Group I was administered 25 mg (140 mg/kg) of Aloe Barbadensis per day both orally and through gavage. Aloe Barbadensis was inside capsules that contain 500 mg of soybean oil; therefore Group II was administered that 500 mg of soybean oil. Group III were the control group. All three groups were nourished on normal feed and water ad libitum. The substance had been administered for 20 days until the birth. Organs involved in reproductive system were examined on histological bases. Tissue of uterus had a hyperemic view, and vessels were distinct and dilated. Neutrophil leukocyte infiltration was detected on all layers from lamina propria to myometrium. Glands were cystic dilated, and epitel had a hyperplasic view some regions. Vascular increase and hypertrophy on endometrium lumen epitel were observed. Vascular increase and hyperemic form of ovary in the group administered with Aloe Barbadensis was notable. Decreasing of primer follicle’s number, increasing of seconder follicle’s number and diminishing of seconder follicle’s diameter have been occurred in ovary. Aloe Barbadensis administered during pregnancy period did not cause fetal death, growth retardation, abortus or anomaly. The histological changes imply angiogenesis effect of Aloe Barbadensis and an effect like estrogen in uterus and an effect like FSH in ovary. This effect did not damage fetus a dose of 140 mg/kg.
Effects of Aloe Barbadensis, a type of Aloe Vera, on reproductive system were investigated during pregnancy. Aloe Vera gel, a commercial and nontherapeutic form of Aloe Barbadensis, was used for this purpose. 3 groups – 1 control and 2 test groups – of female Wistar Albino rats with no birth before were studied. Group I was administered 25 mg (140 mg/kg) of Aloe Barbadensis per day both orally and through gavage. Aloe Barbadensis was inside capsules that contain 500 mg of soybean oil; therefore Group II was administered that 500 mg of soybean oil. Group III were the control group. All three groups were nourished on normal feed and water ad libitum. The substance had been administered for 20 days until the birth. Organs involved in reproductive system were examined on histological bases. Tissue of uterus had a hyperemic view, and vessels were distinct and dilated. Neutrophil leukocyte infiltration was detected on all layers from lamina propria to myometrium. Glands were cystic dilated, and epitel had a hyperplasic view some regions. Vascular increase and hypertrophy on endometrium lumen epitel were observed. Vascular increase and hyperemic form of ovary in the group administered with Aloe Barbadensis was notable. Decreasing of primer follicle’s number, increasing of seconder follicle’s number and diminishing of seconder follicle’s diameter have been occurred in ovary. Aloe Barbadensis administered during pregnancy period did not cause fetal death, growth retardation, abortus or anomaly. The histological changes imply angiogenesis effect of Aloe Barbadensis and an effect like estrogen in uterus and an effect like FSH in ovary. This effect did not damage fetus a dose of 140 mg/kg.
Açıklama
Anahtar Kelimeler
endometriyum, Aloe barbadensis, vücut ağırlığı, folikül, yavru sayısı, tıbbi bitkiler, morfoloji, bitkisel östrojenler, sıçan, üreme organları, dölyatağı, endometrium, Aloe barbadensis, body weight, follicles, litter size, medicinal plants, morphology, plant oestrogens, rats, reproductive organs, uterus
Kaynak
Acta Veterineria Eurasia
WoS Q Değeri
Scopus Q Değeri
Cilt
34
Sayı
1
Künye
Kosif, R., Aktaş, R. N. ve Birincioğlu, S. (2008). Aloe Barbadensis'in reproduktif sisteme etkisinin araştırılması / Investigation of effects of Aloe Barbadensis on reproductive system. Acta Veterineria Eurasia, İstanbul Üniversitesi Veteriner Fakültesi Dergisi. 34(1), s. 21-38.
