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    Depressive syndrome in the structure of the premanifest stage of schizo phrenia and diseases of the schizo phrenic spectrum and its dynamics and treatment at the stage of the manifestation
    (Maltepe Üniversitesi, 2018) Serhiiovich, Kostyuchenkov Oleksii
    Relevance: Many researchers (Nadzharov R.A., 1969, Snezhnevsky A.V., 1983, Tsirkin S.Yu., 1998; Kotsyubinsky A.P., 2004; Melnikova Yu.V., 2008) noted that the pre-manifest period of schizophrenia (S) and diseases of the schizophrenic spectrum (DSS) are characterized by an unexpressed, rudimentary psychopathological symptomatology, a feature prominently among which affective symptoms occupy. Recently, there has been a trend towards an increase in depressive manifestations during S and DSS both during the home period and during the manifestation of the disease. More often in the structure of the first attack of S and DSS there are depressive-paranoid, depressivehypochondriac syndromes, as well as postpsychotic depression. Study aims: Identification in the syndromic structure of the 1st attack of the S and DSS of the depressive component and determination of the most effective drug treatment of these disorders. Materials and approaches: The study involved 75 patients with 1-st psychotic episode within the framework of the S and DSS, whose syndromic structure included the components of the depressive syndrome. All patients were treated in one of the departments of the CMPI «Slavyansk Regional Psychiatric Hospital» and applied for inpatient care only after 1-4 months of outpatient treatment with antidepressants. Results: Among patients with a depressive-paranoid syndrome who received outpatient monotherapy with antidepressants, in 3 cases the mitigation of depressive symptoms was noted, in 13 cases the condition remained without dynamics, in 15 cases the condition worsened with the increase of tension, fear, increased delirium, and disturbances in the associative process. Combined treatment of this group of patients with neuroleptics and small doses of antidepressants caused more favorable dynamics with simultaneous mitigation of depression, de-activation of delusional experiences, normalization of the associative process. Conclusions: Thus, in all these groups of patients, when the depressive component was present in the structure of the psychopathological syndrome, combined therapy with antidepressants and antipsychotics led to greater treatment effectiveness than monotherapy of only one of these groups of drugs.
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    Depressive syndrome in the structure of the premanifest stage of schizophrenia and diseases of the schizophrenic spectrum and its dynamics and treatment at the stage of the manifestation
    (Maltepe Üniversitesi, 2018) Serhiiovich, Kostyuchenkov Oleksii; Çakıl, Yaprak Dönmez; Öztopcu, Aslı; Öztürk, Şenay; Özünal, Zeynep Güneş
    Marry researches (Nadzharov R.A. 1969, Snezhnevsky A.V. 1983, Tsirkin S.Yu,1998: Kotsyubinsky A.P., 2004; Melnikoa Yu.V. 2008) noted that the pre-manifest period of schizophrenia (S) and diseases of the schizophrenic spectrum (DSS) are characterized by an unexpressed, rudimentary psychopathological symptomatology, a feature prominently among which affective symptoms occupy.