Safen Ven grefti hazırlanmasında endotelin nitroprussid ile korunması
Küçük Resim Yok
Tarih
2001
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Turkish Society of Cardiovascular Surgery
Erişim Hakkı
CC0 1.0 Universal
info:eu-repo/semantics/openAccess
info:eu-repo/semantics/openAccess
Özet
Bu çalışmada, koroner bypass cerrahisinde kullanılan safen ven grefti için iyi bir hazırlama tekniğini tespit etmek amacıyla solüsyon değişkenlerinin ven morfolojisine olan etkisi araştırıldı. Koroner bypass ameliyatı yapılan 10 hastadan alınan safen ven greft örnekleri her biri en az 3 cm boyunda olmak üzere üç ayrı gruba ayrıldı. Grup I kontrol grubu olarak kabul edildi. Grup II’de serum fizyolojik, Grup III’de nitroprussid solüsyonunda eşit süreli olarak bekletilerek kontrol grubunda 20 mmHg, diğer gruplar da ortalama 100 mmHg basınçla safen ven greftleri şişirildi. Safen ven grefti örnekleri hazırlık aşamasından sonra ışık mikroskopisinde incelendi. Gruplar endotelyal hücre kaybı, intima ve mediadaki ödeme göre 0-3 arasında skorlanarak değerlendirildi. Her grup için ortalama skorlar karşılaştırıldığında nitroprussid kullanılan grupta sonuçların daha iyi olduğu görüldü. Sonuç olarak, nitroprussid solüsyonu ile hazırlanan safen ven greftlerinde endotelin daha iyi korunduğu tespit edildi.
In this study we investigated to find out one of the best preparation technique by the effect of different solutions on venous morphology for harvested saphenous vein graft for CABG. Saphenous veins harvested from 10 patients were divided into three groups, and saphenous veins were divided to 3 cm segments. Group I was the control group and saphenous vein graft was enlarged by 20 mmHg, in Group II saphenous vein graft put in isotonic sodium chloride for 20 minutes and enlarged by 100 mmHg, and Group III saphenous vein graft was put in nitroprusside for 20 minutes and enlarged by 100 mmHg pressure. All saphenous vein segments were examined under light microscope for endothelial cell deprivation, intimal and medial edema and scored from 0 to 3. Mean scores were collected as datas. In nitroprusside group all scoring datas were better. As a result we found out that nitroprusside was having better protective effect on saphenous vein endothelium.
In this study we investigated to find out one of the best preparation technique by the effect of different solutions on venous morphology for harvested saphenous vein graft for CABG. Saphenous veins harvested from 10 patients were divided into three groups, and saphenous veins were divided to 3 cm segments. Group I was the control group and saphenous vein graft was enlarged by 20 mmHg, in Group II saphenous vein graft put in isotonic sodium chloride for 20 minutes and enlarged by 100 mmHg, and Group III saphenous vein graft was put in nitroprusside for 20 minutes and enlarged by 100 mmHg pressure. All saphenous vein segments were examined under light microscope for endothelial cell deprivation, intimal and medial edema and scored from 0 to 3. Mean scores were collected as datas. In nitroprusside group all scoring datas were better. As a result we found out that nitroprusside was having better protective effect on saphenous vein endothelium.
Açıklama
Anahtar Kelimeler
Safen ven grefti, endotel hasarı, nitroprussid, Saphenous vein graft, endothelial injury, nitroprusside
Kaynak
Turkish Journal of Thoracic and Cardiovascular Surgery
WoS Q Değeri
Scopus Q Değeri
Q3
Cilt
9
Sayı
Künye
Us, M. H., Pekediz, A., İnan, K., Çağlı, K., Cingözbay, B. Y., Yıldırım, Ş., Duran, E. ve Öztürk, Ö. Y. (2001). Safen Ven grefti hazırlanmasında endotelin nitroprussid ile korunması / Protection saphenous vein graft endothelium with nitroprusside solution. Turkish Journal of Thoracic and Cardiovascular Surgery, Turkish Society of Cardiovascular Surgery. 9, s. 105-108.
