Hepatit B virüsüne bağlı kronik infeksiyon ve kronik hepatit hastalarının klinik ve laboratuvar özelliklerinin irdelenmesi / Examination of clinical and laboratory features of chronic infection and chronic hepatitis cases due to hepatitis B virus
Yükleniyor...
Tarih
2021
Yazarlar
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Maltepe Üniversitesi
Erişim Hakkı
Attribution-NonCommercial-NoDerivs 3.0 United States
info:eu-repo/semantics/openAccess
info:eu-repo/semantics/openAccess
Özet
Amaç: Avrupa Karaciğer Çalışma Derneği 2017 kılavuzunda HBV infeksiyonun eski terminolojideki immuntoleran ve inaktif taşıyıcı terimi kronik infeksiyon (Kİ), eski terminolojide immun reaktif terimi ise kronik hepatit (KH) olarak sınıflandırılmıştır. Bu çalışmada Kİ ve KH olan hastalarda, klinik ve laboratuvar özelliklerinin irdelenmesi amaçlanmıştır. Materyal ve Metodlar: Ocak 2019 ile Ocak 2020 tarihleri arasında kronik HBV infeksiyonu tanısıyla polikliniğine başvuran >18 yaş olguların klinik ve laboratuvar özellikleri geriye dönük olarak incelendi. Olgular Kİ ve KH olarak iki gruba ayrıldı. Olguların ultrasonografik sonuçları incelenerek hepatosteatoz bulguları grade 0, 1, 2 ve 3 olarak kaydedildi. Bulgular: Yüz altmış (kadın: 87, erkek: 73) hasta incelenmiştir. Her iki grup arasında yaş ve cinsiyet açısından anlamlı bir fark bulunmadı (sırasıyla p=0.20; p=021). Aspartat aminotransferaz (AST) ve Alanin aminoteransferaz (ALT) KH grubunda Kİ grubuna göre daha yüksek bulundu (sırasıyla p<0,001, p=0,03). Ortalama trombosit değeri KH grubunda, Kİ grubuna göre daha düşük saptandı (p=0,04). Evre 2 hepatosteatoz Kİ grubunda olguların %17’sinde saptanırken KH grubunda olguların %3’ünde saptandı (p=0,003). Sonuç: Kİ ve KH olan hastaların fibroz evresinin ilerlemeden tanı ve tedaviye ulaşması için klinik laboratuvar ve görüntüleme yöntemleriyle yakından izlenmesinin gerekli olduğu kanısına varılmıştır.
Aim: In theEuropean Liver Study Association 2017 guideline, the term immune tolerant and inactive carrier of HBV infection in the old terminology is classified as chronic infection (CI), and the term immune reactive in the old terminology is classified as chronic hepatitis (CH). In this study, it was aimed to examine the clinical and laboratory features of patients with CI and CH. Material and Methods: Between January 2019 and January 2020, the clinical and laboratory features of patients aged> 18 years who were admitted to the infectious diseases outpatient clinic with the diagnosis of chronic HBV infection were retrospectively analyzed. The cases were divided into two groups as CI and CH. The ultrasound results of the cases were examined and hepatosteatosis findings were recorded as grade 0, 1, 2 and 3. Results: One hundred and sixty (female: 87, male: 73) cases were examined. There was no significant difference between the two groups in terms of age and gender (respectively p= 0.20; p=021). Aspartate aminotransferase and Alanine aminoteransferase was higher in the CH group then CI group (respectively p<0.001, p=0.03) .The mean platelet value was lower in the CH group then CI gruop (p=0.04). Grade 2 hepatosteatosis was detected in 17% of thecases in the CI group, and in 3% of the cases in the CH group (p=0.003). Conclusion: It was concluded that patients with CI and CH should be closely monitored by clinical laboratory and imaging methods in order to achieve diagnosis and treatment before the fibrosis stage progresses.
Aim: In theEuropean Liver Study Association 2017 guideline, the term immune tolerant and inactive carrier of HBV infection in the old terminology is classified as chronic infection (CI), and the term immune reactive in the old terminology is classified as chronic hepatitis (CH). In this study, it was aimed to examine the clinical and laboratory features of patients with CI and CH. Material and Methods: Between January 2019 and January 2020, the clinical and laboratory features of patients aged> 18 years who were admitted to the infectious diseases outpatient clinic with the diagnosis of chronic HBV infection were retrospectively analyzed. The cases were divided into two groups as CI and CH. The ultrasound results of the cases were examined and hepatosteatosis findings were recorded as grade 0, 1, 2 and 3. Results: One hundred and sixty (female: 87, male: 73) cases were examined. There was no significant difference between the two groups in terms of age and gender (respectively p= 0.20; p=021). Aspartate aminotransferase and Alanine aminoteransferase was higher in the CH group then CI group (respectively p<0.001, p=0.03) .The mean platelet value was lower in the CH group then CI gruop (p=0.04). Grade 2 hepatosteatosis was detected in 17% of thecases in the CI group, and in 3% of the cases in the CH group (p=0.003). Conclusion: It was concluded that patients with CI and CH should be closely monitored by clinical laboratory and imaging methods in order to achieve diagnosis and treatment before the fibrosis stage progresses.
Açıklama
Anahtar Kelimeler
Hepatit B virüsü, kronik hepatit B infeksiyonu, karaciğer fibrozu, Hepatitis B virus, chronic hepatitis B infection, liver fibrosis
Kaynak
Maltepe Tıp Dergisi
WoS Q Değeri
Scopus Q Değeri
Cilt
13
Sayı
2
Künye
Hamidi, A. A., Keşçioğlu, S. ve Karadeniz. A. (2021). Hepatit B virüsüne bağlı kronik infeksiyon ve kronik hepatit hastalarının klinik ve laboratuvar özelliklerinin irdelenmesi / Examination of clinical and laboratory features of chronic infection and chronic hepatitis cases due to hepatitis B virus. Maltepe Tıp Dergisi, Maltepe Üniversitesi. 13(2), s. 57-60.
