Beneficial effects of melatonin on reperfusion injury in rat sciatic nerve

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dc.authorid0000-0003-2651-8353en_US
dc.authorid0000-0001-9328-9373en_US
dc.authorid0000-0002-4474-7371en_US
dc.contributor.authorSayan, Hale
dc.contributor.authorÖzaçmak, Veysel Haktan
dc.contributor.authorÖzen, Oğuz Aslan
dc.contributor.authorCoşkun, Ömer
dc.contributor.authorArslan, Seyfullah Oktay
dc.contributor.authorSezen, S. Cem
dc.date.accessioned2024-07-12T21:04:50Z
dc.date.available2024-07-12T21:04:50Z
dc.date.issued2004en_US
dc.departmentFakülteler, Tıp Fakültesien_US
dc.description.abstractStudies have shown that ischemia–reperfusion (I/R) produces free radicals leading to lipid peroxidation and to damage of the nervous tissue. Melatonin, a main secretory product of the pineal gland, has free radical scavenging and antioxidant properties and has been shown to diminish I/R injury in many tissues. There are a limited number of studies related to the effects of melatonin on I/R injury in the peripheral nervous system. Therefore, in the present study, the protective effect of melatonin was investigated in rats subjected to 2?hr of sciatic nerve ischemia followed by 3?hr of reperfusion. Following reperfusion, nerve tissue samples were collected for quantitative assesment of malondialdehyde (MDA), an oxidative stress marker, and superoxide dismutase (SOD), a principal antioxidant enzyme. Samples were further evaluated at electron microscopic level to examine the neuropathological changes. I/R elevated the concentration of MDA significantly while there was a reduction at SOD levels. Melatonin treatment reversed the I/R?induced increase and decrease in MDA and SOD levels, respectively. Furthermore, melatonin salvaged the nerve fibers from ischemic degeneration. Histopathologic findings in the samples of melatonin?treated animals indicated less edema and less damage to the myelin sheaths and axons than those observed in the control samples. Our results suggest that administration of melatonin protects the sciatic nerve from I/R injury, which may be attributed to its antioxidant property.en_US
dc.identifier.citationSayan, H., Ozacmak, V.H., Ozen, O.A., Coskun, O., Arslan, S.O., Sezen, S.C. ve Aktas, R.G. (2004). Beneficial effects of melatonin on reperfusion injury in rat sciatic nerve. Journal of Pineal Research, Wiley. 37(3), s. 143-148.en_US
dc.identifier.endpage148en_US
dc.identifier.issn0742-3098
dc.identifier.issn1600-079X
dc.identifier.issue3en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage143en_US
dc.identifier.urihttps://onlinelibrary.wiley.com/doi/abs/10.1111/j.1600-079X.2004.00145.x?sid=nlm%3Apubmed
dc.identifier.urihttps://hdl.handle.net/20.500.12415/3842
dc.identifier.volume37en_US
dc.institutionauthorAktas, Ranan Gulhan
dc.language.isoenen_US
dc.publisherWileyen_US
dc.relation.ispartofJournal of Pineal Researchen_US
dc.relation.isversionof10.1111/j.1600-079X.2004.00145.xen_US
dc.relation.publicationcategoryUluslararası Hakemli Dergide Makale - Kurum Öğretim Elemanıen_US
dc.rightsCC0 1.0 Universal*
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.rights.urihttp://creativecommons.org/publicdomain/zero/1.0/*
dc.snmzKY02018
dc.subjectfree radical scavengeren_US
dc.subjectmalondialdehydeen_US
dc.subjectmelatoninen_US
dc.subjectoxidative stressen_US
dc.subjectraten_US
dc.subjectreperfusion injuryen_US
dc.subjectsciatic nerveen_US
dc.subjectsuperoxide dismutaseen_US
dc.titleBeneficial effects of melatonin on reperfusion injury in rat sciatic nerveen_US
dc.typeArticle
dspace.entity.typePublication

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