Short term follow up results of the first human uterus transplantation from cadaver

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dc.contributor.authorAkar, M. Erman
dc.contributor.authorÖzkan, O.
dc.contributor.authorErdoğan, O.
dc.contributor.authorCincik, Mehmet
dc.contributor.authorMutlu, D.
dc.contributor.authorGunseren, F.
dc.contributor.authorPestereli, E.
dc.contributor.authorKocak, H.
dc.contributor.authorDinckan, A.
dc.contributor.authorHadimioglu, N.
dc.contributor.authorSuleymanlar, G.
dc.date.accessioned2024-07-12T21:14:14Z
dc.date.available2024-07-12T21:14:14Z
dc.date.issued2012en_US
dc.departmentFakülteler, Tıp Fakültesien_US
dc.description.abstractStudy Objective: To present the short term follow up results of the first human uterus transplantation from cadaver. Design: Case report. Setting: University hospital. Patients: A 19 year old female patient with complete mullerian agenesis presented with primary amenorrhea and inability to achieve intercourse. Intervention: Vaginal reconstruction with jejunum graft, in vitro fertilization and embryo vitrification procedures were performed. Following immunocompatibility tests for the transplantation, the patient was elected as the most suitable recipient for the uterus. The cadaver uterus was screened for the presence of any structural abnormalities and infections preoperatively. Uterus transplantation procedure consisted of revascularisation, reanastomoses of the right and left uterine arteries and veins(ishemia time for five hours), fixation of the uterovesical flap to the preexisting urinary bladder, suspension of the uterosacral ligament to sacrum. Measurements and Main Results: Early postoperative course was uneventful. Intraoperative and postoperative induction immunosuppressive therapy with thymoglobulin, tacrolimus, mycophenolate mofetil and prednisone was well tolerated. Maintanance immunosuppressive therapy with tacrolimus, mycophenolate mofetil and prednisone and prophylactic antiviral, antibacterial therapy was initiated. Bilateral uterine artery doppler ultrasonography showed good perfusion. We observed no signs of rejection and infection confirmed with laboratory and cytological findings. She has had six menstrual cycles since the operation. Conclusion: We have described restoration of menstrual cycles following uterus transplantation which might be a promising option to restore fertility in this selected group of patients.en_US
dc.identifier.citationAkar, M. E., Özkan, O., Erdoğan, O., Cincik, M., Mutlu, D., Gunseren, F., Pestereli, E., Kocak, H., Dinckan, A., Hadimioglu, N. ve Suleymanlar, G. (2012). Short term follow up results of the first human uterus transplantation from cadaver. 41st AAGL Global Congress of Minimally Invasive Gynecology, Elsevier. p. 83.en_US
dc.identifier.startpage83en_US
dc.identifier.urihttps://www.jmig.org/article/S1553-4650(12)00943-0/fulltext#%20
dc.identifier.urihttps://hdl.handle.net/20.500.12415/4599
dc.language.isoenen_US
dc.publisherElsevieren_US
dc.relation.ispartof41st AAGL Global Congress of Minimally Invasive Gynecologyen_US
dc.relation.isversionof10.1016/j.jmig.2012.08.610en_US
dc.relation.publicationcategoryUluslararası Konferans Öğesi - Başka Kurum Yazarıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.snmzKY09208
dc.titleShort term follow up results of the first human uterus transplantation from cadaveren_US
dc.typePresentation
dspace.entity.typePublication

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