A randomised comparison of ganirelix and cetrorelix use in ICSI cycle of women with polycystic ovary syndrome

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dc.authorid0000-0002-4474-7371en_US
dc.contributor.authorKars, Bülent
dc.contributor.authorSofuoğlu, K.
dc.contributor.authorÇalışkan, Erhan
dc.contributor.authorÖztekin, D. C.
dc.contributor.authorTuğ, Niyazi
dc.date.accessioned2024-07-12T21:03:49Z
dc.date.available2024-07-12T21:03:49Z
dc.date.issued2007en_US
dc.departmentFakülteler, Tıp Fakültesien_US
dc.description.abstractOBJECTIVE: To compare the ICSI outcome of two multidose gonadotropin releasing hormone antagonist (GnRH-ant) in women with polycystic ovary syndrome (PCOS). DESIGN: A prospective, randomized, single-blind study in a referral center for assisted reproduction. MATERIALS AND METHODS: Eighty two women with the diagnosis of PCOS were randomly assigned to either multidose ganirelix or multidose cetrorelix, started when the dominant follicle has reached >13 mm in diameter. The sample size calculation was based on an average of 36% clinical pregnancy rate. To find a 16% change in the clinical pregnancy rate with a power of 0.80 at a ¼ 0.05, the total sample size required was 71 women. In order to achieve adequate sample size after cycle cancellation 82 women were recruited in the study. Chi-square and student-t test were used as appropriate. RESULTS: The mean age, the body mass index, infertility period, cleavage rate, fertilisation rates were similar in the two groups (P>0.05). The cycle cancellation rate was 14.6% in the ganirelix group and 12.2% in the cetrorelix group (P¼0.07). The number of good quality embryos obtained was 2.8 0.6 in the ganirelix group while it was 2.6 0.5 in the cetrorelix group. The clinical pregnancy rate was 40% in the ganirelix group and 30.6% in the cetrorelix group (P¼0.4). Take home baby rate were 31.4% in the ganirelix group and 22.2% in the cetrorelix group (P¼0.38). CONCLUSIONS: The two GnRH-ant were found to have similar ICSI outcomes in PCOS patients.en_US
dc.identifier.citationKars, B., Sofuoğlu, K., Çalışkan, E., Öztekin, D. C., Aktaş, R. G. ve Tuğ, N. (2007). A randomised comparison of ganirelix and cetrorelix use in ICSI cycle of women with polycystic ovary syndrome. Fertility and Sterility, Elsevier. 88, s. 181.en_US
dc.identifier.endpage181en_US
dc.identifier.issn0015-0282
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage181en_US
dc.identifier.urihttps://www.fertstert.org/article/S0015-0282(07)02280-7/abstract
dc.identifier.urihttps://hdl.handle.net/20.500.12415/3706
dc.identifier.volume88en_US
dc.institutionauthorAktas, Ranan Gulhan
dc.language.isoenen_US
dc.publisherElsevieren_US
dc.relation.ispartofFertility and Sterilityen_US
dc.relation.isversionof10.1016/j.fertnstert.2007.07.624en_US
dc.relation.publicationcategoryUluslararası Hakemli Dergide Makale - Kurum Öğretim Elemanıen_US
dc.rightsCC0 1.0 Universal*
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.rights.urihttp://creativecommons.org/publicdomain/zero/1.0/*
dc.snmzKY01017
dc.titleA randomised comparison of ganirelix and cetrorelix use in ICSI cycle of women with polycystic ovary syndromeen_US
dc.typeArticle
dspace.entity.typePublication

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