Frequency of precore/core mutants in chronic Hepatitis B cases

Basit Öğe Kaydı
dc.authoridakduman alaşehir, elçin/0000-0002-7710-3759en_US
dc.authoridSanlidag, Tamer/0000-0002-6015-8032en_US
dc.contributor.authorAkçalı, Sinem
dc.contributor.authorSanlidag, Tamer
dc.contributor.authorBicmen, Can
dc.contributor.authorÖzbakkaloğlu, Beril
dc.contributor.authorAlasehir, Elcin Akduman
dc.date.accessioned2024-07-12T21:37:16Z
dc.date.available2024-07-12T21:37:16Z
dc.date.issued2013en_US
dc.department[Belirlenecek]en_US
dc.description.abstractObjective: In recent years, the presence of precore/core region mutations were uncovered by the examination of Hepatitis B Virus (HBV) deoxyribonucleic acid (DNA) that is isolated from patient samples with anti-HBe seroconversion without viral replication loss. In this study, the frequency of precore/core mutations were investigated on serum samples obtained from chronic hepatitis B patients. Methods: From a total of 100 samples 69 anti-HBe and HBV DNA positive, and 31 HBeAg and HBV DNA positive samples were analyzed in the study to determine the mutations with the INNO-LIPA method at the Serology laboratory. Statistical analyses were bone with, SPSS v11.5 and chi-square and variance analysis (ANOVA) tests were conducted. Results: The precore mutations were detected in 68, while the core promoter mutations were present in 57 samples. Mutations were detected at the precore region in 11 out of 31 HBeAg positive (35%), and 57 out of 69 anti-HBe positive samples (83%). Likewise, the core promoter region was affected in 10 of 31 HBeAg (32%), and 47 out of 69 anti-HBe positive samples (68%). Both precore and core promoter mutations were substantially higher in the anti-HBe positive group (p<0.05). Conclusion: As a result, since precore/core mutations were prevalent in samples obtained from the study group, it is our opinion that careful attention must be paid to such mutations during the diagnosis and treatment phases of chronic hepatitis B patients.en_US
dc.identifier.doi10.5222/buchd.2013.110
dc.identifier.endpage116en_US
dc.identifier.issn2146-2372
dc.identifier.issn1309-9566
dc.identifier.issue2en_US
dc.identifier.startpage110en_US
dc.identifier.urihttps://doi.org/10.5222/buchd.2013.110
dc.identifier.urihttps://hdl.handle.net/20.500.12415/6727
dc.identifier.volume3en_US
dc.identifier.wosWOS:000420506800006en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Science
dc.language.isotren_US
dc.publisherDr Behcet Uz Cocuk Hastaliklari Ve Cerrahisien_US
dc.relation.ispartofIzmir Dr Behcet Uz Cocuk Hastanesi Dergisien_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.snmzKY04069
dc.subjectHbeagen_US
dc.subjectAnti-Hbeen_US
dc.subjectHbv-Dnaen_US
dc.subjectPrecoreen_US
dc.subjectCoreen_US
dc.subjectMutationen_US
dc.titleFrequency of precore/core mutants in chronic Hepatitis B casesen_US
dc.typeArticle
dspace.entity.typePublication

Dosyalar

Koleksiyon

WoS İndeksli Yayınlar Koleksiyonu