The effects of alpha-lipoic acid on nitric oxide synthetase dispersion in penile function in streptozotocin-induced diabetic rats

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dc.contributor.authorHurdag, C
dc.contributor.authorOzkara, H
dc.contributor.authorCitci, S
dc.contributor.authorUyaner, I
dc.contributor.authorDemirci, C
dc.date.accessioned2024-07-12T21:49:55Z
dc.date.available2024-07-12T21:49:55Z
dc.date.issued2005en_US
dc.departmentMaltepe Üniversitesien_US
dc.description.abstractDiabetes-induced erectile dysfunction is one of the most prevalent complications of diabetes in males. alpha-Lipoic acid (ALA) and its reduced form, dihydrolipoic acid, are powerful antioxidants. Data strongly suggest that, because of its antioxidant properties, ALA is particularly suited to the prevention and/or treatment of diabetic complications that arise from overproduction of reactive oxygen and nitrogen. The aim of this study was to investigate the localization of nitric oxide synthetase (NOS) in normal and diabetic rat cavernous smooth muscles and to examine the effects of ALA on them. Pats were divided into four groups: control, diabetic, diabetic plus ALA, and ALA only. Penile tissues were taken 15 days after drug application and examined histochemically and immunohistochemically. Comparison of the control and diabetic groups revealed that the axons of nerve cells were not identified with Masson trichrome in the diabetic group, whereas in the control group NOS localization and immunostaining (endothelial NOS [eNOS]) were normal. Diabetic rats administered ALA showed improvement in Masson trichrome, nicotinamide adenine dinucleotide phosphate diaphorase (NADPH-d) and eNOS localization compared with untreated diabetic rats. Although there was no difference between the control group and the group administered ALA only, we observed an increase in NADPH-d and eNOS. In erection, eNOS and neuronal NOS (nNOS) may have a significant role. In pathologic conditions, erectile dysfunction may occur as a result of an increase in inducible macrophage-type NOS (iNOS).en_US
dc.identifier.endpage150en_US
dc.identifier.issn0250-0868
dc.identifier.issue3en_US
dc.identifier.pmid16372481en_US
dc.identifier.startpage145en_US
dc.identifier.urihttps://hdl.handle.net/20.500.12415/8108
dc.identifier.volume27en_US
dc.identifier.wosWOS:000233911100010en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakPubMed
dc.language.isoenen_US
dc.publisherBIOSCIENCE EDIPRINT INCen_US
dc.relation.ispartofINTERNATIONAL JOURNAL OF TISSUE REACTIONS-EXPERIMENTAL AND CLINICAL ASPECTSen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.snmzKY01309
dc.titleThe effects of alpha-lipoic acid on nitric oxide synthetase dispersion in penile function in streptozotocin-induced diabetic ratsen_US
dc.typeArticle
dspace.entity.typePublication

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