Slx5/Slx8 SUMO-targeted ubiquitin ligase deficiency shortens lifespan due to increased mutation accumulation in yeast

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dc.contributor.authorThomas, Pınar Buket
dc.contributor.authorKaluç, Nur
dc.contributor.authorÇavli, Irmak N.
dc.contributor.authorTuna, Bilge G.
dc.date.accessioned2025-01-10T11:28:06Z
dc.date.available2025-01-10T11:28:06Z
dc.date.issued2024
dc.departmentFakülteler, Tıp Fakültesi, Temel Tıp Bilimleri Bölümü, Tıbbi Biyoloji ve Genetik Anabilim Dalı
dc.description.abstractChronological lifespan (CLS) in budding yeast Saccharomyces cerevisiae, which is defined as the time nondividing cells in saturation remain viable, has been utilized as a model to study post-mitotic aging in mammalian cells. CLS is closely related to entry into and maintenance of a quiescent state. Many rearrangements that direct the quiescent state enhance the ability of cells to endure several types of stress. SUMO-targeted ubiquitin ligases (STUbLs) play a critical role in mediating an adaptive response to various stresses. In this study, we investigated the effect of a STUbL, Slx5/Slx8, on CLS in budding yeast. We showed that both SLX5 and SLX8 deletions accelerate chronological aging, resulting in a decreased maximum and mean lifespan. slx5Δ cells were capable of entering or maintaining a quiescent state during aging. On the other hand, aging slx5Δ and slx8Δ cells had both increased spontaneous mutation accumulation. Our data together indicate that Slx5/Slx8 STUBL is required for normal rate of aging by preventing increased spontaneous mutation accumulation during aging.
dc.identifier.citationThomas, P. B., Kaluç, N., Çavli, I. N. ve Tuna, B. G. (2024). Slx5/Slx8 SUMO-targeted ubiquitin ligase deficiency shortens lifespan due to increased mutation accumulation in yeast, FEMS Microbiology Letters, Oxford University Press,--.
dc.identifier.doi10.1093/femsle/fnae109
dc.identifier.issn03781097
dc.identifier.urihttps://doi.org/10.1093/femsle/fnae109
dc.identifier.urihttps://hdl.handle.net/20.500.12415/13226
dc.language.isoen
dc.publisherOxford University Press
dc.relation.ispartofFEMS Microbiology Letters
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectSlx5/Slx8 STUbL (Sumo-Targeted Ubiquitin Ligase)
dc.subjectChronological Aging
dc.subjectQuiescence
dc.subjectMutation Accumulation
dc.subjectSaccharomyces Cerevisiae
dc.titleSlx5/Slx8 SUMO-targeted ubiquitin ligase deficiency shortens lifespan due to increased mutation accumulation in yeast
dc.typeArticle
dspace.entity.typePublication

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