Safe and effective sedation and analgesia for bone marrow aspiration procedures in children with alfentanil, remifentanil and combinations with midazolam

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dc.authorid0000-0002-8335-1927en_US
dc.contributor.authorAntmen, Bülent
dc.contributor.authorŞaşmaz, Ilgen
dc.contributor.authorBirbiçer, Handan
dc.contributor.authorÖzbek, Hayri
dc.contributor.authorBurgut, Hüseyin Refik
dc.contributor.authorIşık, Geylan
dc.contributor.authorKılınç, Yurdanur
dc.date.accessioned2024-07-12T21:10:38Z
dc.date.available2024-07-12T21:10:38Z
dc.date.issued2005en_US
dc.departmentFakülteler, Tıp Fakültesien_US
dc.description.abstractBackground: Invasive procedures such as bone marrow aspiration in children may be painful and cause anxiety. We investigated the efficacy and safety of remifentanil (R) alfentanil (A), remifentanil-midazolam (RM), and alfentanil-midazolam (AM) combinations in providing analgesia and sedation for bone marrow aspiration. Methods: Eighty children undergoing a diagnostic bone marrow aspiration whose ages ranged from 5-16 years (mean 9.20 +/- 3.00 years) were enrolled in this study. The patients were randomly assigned to one of 4 treatment groups. Vital signs, sedation and pain scores, somatic responses (sweating and tears) were recorded before, during bone marrow aspiration and after 5 and 15 min of the procedure. Results: There were no statistical differences between sedation and the CHEOPS scores of the four groups during and after the procedures. The VAS scores were significantly higher for group A compared with groups R and RM during the procedure (P < 0.008). There were no differences between the VAS scores in group AM compared with groups R and RM (P > 0.008). There were also no statistical differences among the VAS scores of four groups after the procedure (P > 0.008). All patients had adequate sedation and analgesia. None of the patients in the study had deep sedation, hypotension, bradycardia, hypoxemia, or respiratory depression. Conclusions: Remifentanil, alfentanil, remifentanil-midazolam, and alfentanil-midazolam combinations are effective in children and can be used safely in bone marrow aspiration which is a brief but painful procedure performed in the pediatric patient group.en_US
dc.identifier.citationAntmen, B., Şaşmaz, I., Birbiçer, H., Özbek, H., Burgut, H. R., Işık, G. ve Kılınç, Y. (2005). Safe and effective sedation and analgesia for bone marrow aspiration procedures in children with alfentanil, remifentanil and combinations with midazolam. Pediatric Anesthesia. 15(3), s. 214-219.en_US
dc.identifier.endpage219en_US
dc.identifier.issue3en_US
dc.identifier.startpage214en_US
dc.identifier.urihttps://pubmed.ncbi.nlm.nih.gov/15725319/
dc.identifier.urihttps://hdl.handle.net/20.500.12415/4270
dc.identifier.volume15en_US
dc.institutionauthorBurgut, Hüseyin Refik
dc.language.isoenen_US
dc.publisherNational Center for Biotechnology Informationen_US
dc.relation.ispartofPediatric Anesthesiaen_US
dc.relation.isversionof10.1111/j.1460-9592.2004.01411.xen_US
dc.relation.publicationcategoryUluslararası Hakemli Dergide Makale - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.snmzKY03216
dc.titleSafe and effective sedation and analgesia for bone marrow aspiration procedures in children with alfentanil, remifentanil and combinations with midazolamen_US
dc.typeArticle
dspace.entity.typePublication

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