An analysis of neuropeptides at nasal contact points of patients with secondary headache
Küçük Resim Yok
Tarih
2016
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Wolters Kluwer
Erişim Hakkı
info:eu-repo/semantics/openAccess
Özet
Objectives: This prospective research study was designed to analyze the surgical outcomes and the intensity of substance P (SP), neurokinin A (NA), and calcitonin gene-related peptide (CGRP) in contact and noncontact nasal mucosa of patients with headache. Methods: Twenty adults with secondary headache and correctible nasal obstruction were included in this study. The patients had nasal contact points between the nasal septum and the middle or inferior turbinates on nasal endoscopy and computed tomography scan. During surgical procedures, sample tissues were obtained from the nasal contact point and the noncontact area of the lateral nasal wall of these patients. Fluorescein staining intensity for antibodies against SP, NA, and CGRP was analyzed using image J software. Headaches were evaluated using a visual analog scale preoperatively and postoperatively. Results: The differences between the preoperative and the postoperative 3rd month (P < 0.001) and 12th month (P < 0.001) visual analog scale scores were statistically significant. However, fluorescein staining intensity for SP (P = 0.631), NA (P = 0.546), and CGRP (P = 0.683) did not show statistically significant differences between the contact mucosa and the noncontact mucosa groups. Conclusions: Although in selected patients significant relief of headache can be obtained by surgery, there is no evidence from this study that SP, NA, and CGRP are responsible for the initiation of headache.
Açıklama
Anahtar Kelimeler
Calcitonin gene-related peptide, endoscopic nasal surgery, nasal septal deviation, neurokinin A, neuropeptides
Kaynak
Journal of Craniofacial Surgery
WoS Q Değeri
Scopus Q Değeri
Q2
Cilt
27
Sayı
3
Künye
Demir, D., Cengiz, N., Güven, M. ve Bulduk, O. (2016). An analysis of neuropeptides at nasal contact points of patients with secondary headache. Journal of Craniofacial Surgery, Wolters Kluwer. 27(3), s. 305-309.
