Atipisiz basit endometrial hiperplazi ve menoraji tedavisinde levonorgestrel salgılayan rahim içi aracın (mirena®) etkinliği
Küçük Resim Yok
Tarih
2007
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Türkiye Klinikleri
Erişim Hakkı
CC0 1.0 Universal
info:eu-repo/semantics/openAccess
info:eu-repo/semantics/openAccess
Özet
Amaç: Amacımız, levonorgestrel salgılayan rahim içi aracın menoraji ve atipisiz basit endometrial hiperplazi tedavisindeki etkinliği-nin araştırılmasıdır. Gereç ve Yöntemler: Çalışma; anormal uterin kanama şikayeti ile hastanemize başvuran, endometrial örnekleme sonucunda pato-loji tespit edilmeyen, başlıca yakınması menoraji olan 26 ve endometrial örnekleme sonucunda atipisiz basit endometrial hiperplazi tespit edilen 16 olmak üzere toplam 42 hastayı kap-samaktadır. Hastalara levonorgestrel salgılayan rahim içi araç(LS-RİS) uygulandı. Tedavi öncesi ve tedavinin 6. ayında transvajinal USG’leri yapıldı, Hb-Hct değerleri, kanamalı gün sayısı, siklus süresi, bir günde kullanılan ped sayısı ile endometrial kalınlıkları değerlendirildi. Hastalara 6. ayda pipelle ile endometrial örnekleme yapıldı. Bulgular: Olguların kanamalı gün ve günlük kullanılan ped sayısı anlamlı derecede azalırken (p< 0.05 ve p< 0.001), siklus süresi anlamlı şekilde uzamış olarak izlendi (p< 0.05). Hb ve Hct de-ğerleri altıncı ayın sonunda anlamlı olarak artmıştı (p< 0.05 ve p< 0.01). Endometrial kalınlıkta başlangıç değerlerine göre 6. ayda anlamlı azalma izlendi (p< 0.001). Sonuç: LS-RİS kanama miktarını azaltıp siklus süresini uzatmakta, altıncı ayın sonunda Hb-Hct değerlerinde anlamlı yükselme ve endometrial kalınlıkta azalma sağlamaktadır. Menoraji tedavi-sinde LS-RİS etkin bir tedavi olarak görülmektedir. Atipisiz ba-sit endometrial hiperplazi tedavisinde LS-RİS, kullanım kolay-lığı ve toleransının iyi olması nedeniyle oral gestagen tedavile-rine alternatifken, uzun dönem kullanımının etkinliği nedeniyle histerektomi ve endometrial ablasyona da alternatif olabilir.
Objective: To investigate the effect of levonorgestrel releasing intrauterine device in the treatment of simple endometrial hyperplasia and menorrhagia. Material and Methods: We included a total of 42 patients (26 without any pathology in the endometrial biopsy butmenorrhagia, 16 with simple endometrial hyperplasia). Levonorgestrel releasing intrauterine device (LR-IUD) is placed to the patients. Before the treatment and at the 6th month, transvaginal ultrasonography was performed and Hb-Hct values, days with bleeding, menstruel phase, pads used and endometrial line were evaluated. Endometrial biopsy was performed with pipelle at the 6th month. Results: Days with bleeding and daily pads used by the subjects were decreased (p< 0.05 and p< 0.001), also menstruel cycle period was extended (p< 0.05). Hb and Hct values were increased at the 6th month measurement. Endometrial thickness was significantly decreased at the end of the 6th month (p< 0.001). Conclusion: LR-IUD decreases menstruel bleeding, increases menstruel cycle period. At the end of the 6th month Hb-Hct values were increased and endometrial thickness was decreased. LR-IUD seems to be an effective treatment for menorrhagia. LR-IUD may be an alternative for oral progestagens, surgical procedures and endometrial ablasion in the treatment of endometrial hyperplasia.
Objective: To investigate the effect of levonorgestrel releasing intrauterine device in the treatment of simple endometrial hyperplasia and menorrhagia. Material and Methods: We included a total of 42 patients (26 without any pathology in the endometrial biopsy butmenorrhagia, 16 with simple endometrial hyperplasia). Levonorgestrel releasing intrauterine device (LR-IUD) is placed to the patients. Before the treatment and at the 6th month, transvaginal ultrasonography was performed and Hb-Hct values, days with bleeding, menstruel phase, pads used and endometrial line were evaluated. Endometrial biopsy was performed with pipelle at the 6th month. Results: Days with bleeding and daily pads used by the subjects were decreased (p< 0.05 and p< 0.001), also menstruel cycle period was extended (p< 0.05). Hb and Hct values were increased at the 6th month measurement. Endometrial thickness was significantly decreased at the end of the 6th month (p< 0.001). Conclusion: LR-IUD decreases menstruel bleeding, increases menstruel cycle period. At the end of the 6th month Hb-Hct values were increased and endometrial thickness was decreased. LR-IUD seems to be an effective treatment for menorrhagia. LR-IUD may be an alternative for oral progestagens, surgical procedures and endometrial ablasion in the treatment of endometrial hyperplasia.
Açıklama
Anahtar Kelimeler
Endometrial hiperplazi, menoraji, hormon salgılayan rahim içi araç, Endometrial hyperplasia, menorrhagia, intrauterine devices
Kaynak
Türkiye Klinikleri Jinekoloji Obstetrik
WoS Q Değeri
Scopus Q Değeri
Cilt
1
Sayı
Künye
Günay, T., Tüfekçi, E. C., İlter, E., Akyol, H. ve Öcal, A. (2007). Atipisiz basit endometrial hiperplazi ve menoraji tedavisinde levonorgestrel salgılayan rahim içi aracın (mirena®) etkinliği / The effect of levonorgestrel releasing intrauterine device (mirena®) in the treatment of simple endometrial hyperplasia and menorrhagia. Türkiye Klinikleri Jinekoloji Obstetrik, Türkiye Klinikleri. 1, s. 7-13.
