Intracellular glutathione content in leukemias

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dc.authorid0000-0002-8335-1927en_US
dc.contributor.authorPaydaş, Semra
dc.contributor.authorYüreğir, Güneş T.
dc.contributor.authorŞahin, Berksoy
dc.contributor.authorSeyrek, Ertuğrul
dc.contributor.authorBurgut, Hüseyin Refik
dc.date.accessioned2024-07-12T21:10:32Z
dc.date.available2024-07-12T21:10:32Z
dc.date.issued1995en_US
dc.departmentFakülteler, Tıp Fakültesien_US
dc.description.abstractThe intracellular glutathione (GSH) content was measured in 73 patients with leukemia and compared with controls. GSH content was between 1.16 and 5.55 ?mol/g protein (mean 2.96 ± 0.86) in the study group and between 0.5 and 1.48 ?mol/g protein (mean 1.31 ± 0.27) in the control group, statistically significant difference (p = 0.0000). There was no significant difference between acute and chronic leukemias, lymphoid and myeloid leukemias and, more importantly, newly diagnosed and relapsed patients. GSH content did not change significantly with clinical and hematologic parameters such as age, sex, and initial hematologic findings. In addition, variable changes were detected over 24 h in 9 patients. It can be concluded that GSH content in leukemic cells was higher than in controls and showed a wide range. The absence of a relationship between GSH content and clinical and laboratory parameters suggested that GSH is not the sole determinant of response to cytotoxic drugs. GSH variation over a 24-hour period may be important in the timing and success of chemotherapy for leukemias.en_US
dc.identifier.citationPaydaş, S., Yüreğir, G. T., Şahin, B., Seyrek, B. ve Burgut, H. R. (1995). Intracellular glutathione content in leukemias. Oncology. 52(2), s. 112-115.en_US
dc.identifier.endpage115en_US
dc.identifier.issue2en_US
dc.identifier.startpage112en_US
dc.identifier.urihttps://www.karger.com/Article/Abstract/227440
dc.identifier.urihttps://hdl.handle.net/20.500.12415/4261
dc.identifier.volume52en_US
dc.institutionauthorBurgut, Hüseyin Refik
dc.language.isoenen_US
dc.publisherKarger Publishingen_US
dc.relation.ispartofOncologyen_US
dc.relation.isversionof10.1159/000227440en_US
dc.relation.publicationcategoryUluslararası Hakemli Dergide Makale - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.snmzKY03161
dc.titleIntracellular glutathione content in leukemiasen_US
dc.typeArticle
dspace.entity.typePublication

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