Comparison of COVID-19 Outcomes With Alpha-1 Antitrypsin Deficiency Prevalence in Europe: A Cross-Sectional Study

dc.authoridSezgin, Yılmaz/0000-0002-3626-0264en_US
dc.authoridKAPLAN, ASKIN KESKIN/0000-0003-4326-1529en_US
dc.contributor.authorSezgin, Yılmaz
dc.contributor.authorBecel, Sinan
dc.contributor.authorKaplan, Askin K.
dc.date.accessioned2024-07-12T21:37:49Z
dc.date.available2024-07-12T21:37:49Z
dc.date.issued2023en_US
dc.department[Belirlenecek]en_US
dc.description.abstractIntroduction We hypothesized that the geographic distributions of COVID-19 and alpha-1 antitrypsin alleles prevalence are similar. We investigate whether there is a relationship between the geographical density of the COVID-19 pandemic and the distributions of alpha-1 antitrypsin alleles. Methods This research is a cross-sectional study. Alpha-1 antitrypsin PI*MS, PI*MZ, PI*SS, PI*SZ, and PI*ZZ genotypes frequencies of European countries were compared with the case and death data related to the COVID-19 pandemic as of March 1, 2022. Results A significant relationship was found between the rates of COVID-19 cases and the rates of individuals with alpha-1 antitrypsin PI*MS, PI*MZ, PI*SS, PI*SZ, and PI*ZZ genotypes allele in European countries. Conclusions The findings showed that the prevalence distribution of the alleles of the gene defect that causes alpha-1 antitrypsin insufficiency is related to the prevalence of COVID-19 pandemic data.en_US
dc.identifier.doi10.7759/cureus.34293
dc.identifier.issn2168-8184
dc.identifier.issue1en_US
dc.identifier.pmid36860224en_US
dc.identifier.urihttps://doi.org/10.7759/cureus.34293
dc.identifier.urihttps://hdl.handle.net/20.500.12415/6954
dc.identifier.volume15en_US
dc.identifier.wosWOS:000945749100014en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakPubMed
dc.language.isoenen_US
dc.publisherCureus Incen_US
dc.relation.ispartofCureus Journal of Medical Scienceen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.snmzKY04296
dc.subjectPandemiaen_US
dc.subjectEuropaen_US
dc.subjectPrevalenceen_US
dc.subjectAlpha-1 Antitrypsin Deficiencyen_US
dc.subjectCovid-19en_US
dc.titleComparison of COVID-19 Outcomes With Alpha-1 Antitrypsin Deficiency Prevalence in Europe: A Cross-Sectional Studyen_US
dc.typeArticle
dspace.entity.typePublication

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