The significance of coeliac disease antibodies in patients with ankylosing spondylitis: a case-controlled study

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dc.authorid0000-0002-7907-5472en_US
dc.authorid0000-0002-6867-0073en_US
dc.contributor.authorTogrol, Rıfat Erdem
dc.contributor.authorNalbant, Selim
dc.contributor.authorSolmazgül, Emrullah
dc.contributor.authorÖzyurt, Mustafa
dc.contributor.authorKaplan, Mustafa
dc.contributor.authorKıralp, Mehmet Zeki
dc.contributor.authorDinçer, Ümit
dc.contributor.authorŞahan, Burak
dc.date.accessioned2024-07-12T21:04:44Z
dc.date.available2024-07-12T21:04:44Z
dc.date.issued2009en_US
dc.departmentFakülteler, Tıp Fakültesien_US
dc.description.abstractThe presence of anti-gliadin antibodies (AGA) and their relationship with intestinal permeability and prevalence of undiagnosed coeliac disease (CD) in ankylosing spondylitis (AS) were investigated. Blood samples from 30 AS patients and 19 age- and sex-matched controls were analysed for human leucocyte antigen (HLA)-B27, AGA and endomysial antibodies (EMA). Immunoglobulin (Ig) A-type AGA and IgG-type EMA were determined by enzyme-linked immunosorbent assay. AGA-positive patients were examined by gastroduodenoscope and proximal small bowel mucosa biopsies were performed. Eleven (36.7%) AS patients were AGA positive (compared with none of the control subjects) and three (10.0%) of these AS patients were also EMA-positive. The presence of AGA was not associated with more severe AS. Mild-to-severe villous atrophy and hyperplasia of crypts with increased chronic inflammatory cells in the lamina propria, which is typical of CD, was only observed in one AGA/EMA positive AS patient; CD was subsequently diagnosed by histology. Although AGA positivity might contribute to the pathogenesis of AS by increasing intestinal permeability to micro-organisms or by modifying intestinal immune mechanisms, further work is required to clarify its role in AS.en_US
dc.identifier.citationToğrol R.E., Nalbant S., Solmazgül E., Özyurt M., Kaplan M., Kıralp M.Z., Dinçer U. ve Şahan B. (2009). The significance of coeliac disease antibodies in patients with ankylosing spondylitis: a case-controlled study. Journal of International Medical Research, SageJournals. 37(1), s. 220-226.en_US
dc.identifier.endpage226en_US
dc.identifier.issn0300-0605
dc.identifier.issn1473-2300
dc.identifier.issue1en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage220en_US
dc.identifier.urihttps://pubmed.ncbi.nlm.nih.gov/19215694/
dc.identifier.urihttps://hdl.handle.net/20.500.12415/3826
dc.identifier.volume37en_US
dc.language.isoenen_US
dc.publisherSageJournalsen_US
dc.relation.ispartofJournal of International Medical Researchen_US
dc.relation.isversionof10.1177/147323000903700127en_US
dc.relation.publicationcategoryUluslararası Hakemli Dergide Makale - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.snmzKY01941
dc.subjectAnti-gliadin antibodiesen_US
dc.subjectCoeliac diseaseen_US
dc.subjectAnkylosing spondylitisen_US
dc.subjectSpondyloarthropathyen_US
dc.titleThe significance of coeliac disease antibodies in patients with ankylosing spondylitis: a case-controlled studyen_US
dc.typeArticle
dspace.entity.typePublication

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