Tiroid göz hastalığının korneal biyomekanik özellikler üzerine etkisi
Küçük Resim Yok
Tarih
2019
Yazarlar
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Maltepe Üniversitesi
Erişim Hakkı
info:eu-repo/semantics/openAccess
Özet
Giriş: Tiroid göz hastalığı (TED), Graves hastalarının% 25-50’sini etkileyen en yaygın orbital hastalıktır. Bu hastalarda retro-orbital inflamatuar süreçler kornea biyomekanik özelliklerini düzenleyebilir. In-vivo kornea biyomekanik parametreleri, Oküler Tepki Analizörü (ORA) kullanılarak değerlendirilebilir. TED’in şiddeti bir NOSPECS derecelendirme sistemi ile tanımlanabilir. Bu çalışmada, korneal biyomekanik parametreler TED’li hastalar ile sağlıklı grup arasında karşılaştırıldı. Hastaların NOSPECS sınıflandırması, biyomekanik değişiklikler ve hastalık şiddeti arasındaki ilişkiyi tanımlamak için de kullanılır. Materyal ve Metodlar: Bu çalışmaya, beş yıldan uzun bir süredir tiroid hastalığı tanısı konan, tiroid göz hastalığı olan 22 hasta ve 47 sağlıklı katılımcı dahil edildi. Tüm olgulara tam endokrinolojik ve oftalmolojik muayene yapıldı. NOSPECS sınıflandırması hafif (derece 1-3) ve ağır (derece 3-6) hastalık olarak değerlendirildi ve gruplandı. Her grup için kornea histerezisi (CH), kornea direnç faktörü (CRF), merkezi kornea kalınlığı (CCT), Goldmann ile ilişkili göz içi basıncı (IOPg) ve korneal kompanse göz içi basıncı (IOPcc) parametreleri, Oküler Tepki Analizcisi ile ölçüldü. Sonuçlar: TED hastalarında yaş ortalaması 38,8 ± 11,6, kontrol grubu için 44,6 ± 16,0 idi. Ortalama CRF, CH ve KKT değerleri, TED hastaları ve sağlıklı katılımcılar için sırasıyla aşağıdaki şekilde ölçüldü: 10.43 +/- 2.04 vs 10.16 +/- 1.90 mmHg, 10.18 +/- 1.81 vs 10.07 +/- 1.71 mmHg ve 550.31+ /-35.73 vs 543 +/- 38.39 mikrom. Bu değerler gruplar arasında anlamlı değildi, ancak TED hastalarında erkeklere göre kadınlarda anlamlı olarak daha yüksekti (p <0,015). Hastaların CRF değerleri ile NOSPECS skoru arasında negatif korelasyon vardı (r = -0.317, p = 0.036). Hafif hastalıklara oranla ciddi oranda düşük CRF hesaplandı (p <0.01). Tartışma: CRF, kadınlarda TED’li erkek hastalara göre anlamlı olarak artmıştır. CRF ayrıca ağır hastalıklarda (NOSPECS 3-6) hafif hastalıklara (NOSPECS 1-3) kıyasla istatistiksel olarak anlamlı bir düşüş gösterdi ve hastalık şiddeti skoru ilerledikçe tedaviyi de azaltmıştır. CRF, klinik uygulamada takip sırasında tiroid göz hastalığı progresyonunu öngörmede güvenilir bir parametre olabilir.
Introduction: Thyroid eye disease (TED) is the most common orbital disease that affects %25-50 of Graves’ patients. In these patients, retro-orbital inflammatory processes can alter corneal biomechanical characteristics. In-vivo corneal biomechanical parameters can be evaluated by using Ocular Response Analyzer (ORA). The severity of TED can be identified with a NOSPECS grading system. In this study, corneal biomechanical parameters are compared between patients with TED and healthy group. The NOSPECS classification of patients is also used to identify relation between biomechanical changes and disease severity. Materials and Methods: In this study, 22 patients with thyroid eye disease, diagnosed with thyroid disease for more than five years, and 47 healthy participants were included. All subjects underwent complete endocrinologic and ophthalmologic examination. The NOSPECS classification was assessed and grouped as mild (grade 1-3) and severe (grade 3-6) disease. For each group, corneal hysteresis (CH), corneal resistance factor (CRF), central corneal thickness (CCT), Goldmann-correlated intraocular pressure (IOPg) and corneal compensated intraocular pressure (IOPcc) parameters were measured by Ocular Response Analyzer. Results: The mean age was 38.8+/-11.6 years for the TED patients and 44.6+/-16.0 years for the control group. The mean values of CRF, CH and CCT were measured for the TED patients and healthy participants as following: 10.43+/-2.04 vs 10.16+/-1.90 mmHg, 10.18+/-1.81 vs 10.07+/-1.71 mmHg, and 550.31+/-35.73 vs 543+/-38.39 microm, respectively. These values were not significant between groups, but they were significantly higher in females compared to males in TED patients (p<0.015). CRF values of patients were negatively correlated with NOSPECS score (r=-0.317, p=0.036). Significantly lower CRF was calculated in severe compared to mild disease (p<0.01). Discussion: CRF was significantly increased in female compared to male patients with TED. CRF also showed statistically significant decrease in severe diseases (NOSPECS 3-6) compared to mild diseases (NOSPECS 1-3) and also revealed down treating as disease severity score progresses. CRF might be a reliable parameter to anticipate thyroid eye disease progression during follow-up in clinical practice.
Introduction: Thyroid eye disease (TED) is the most common orbital disease that affects %25-50 of Graves’ patients. In these patients, retro-orbital inflammatory processes can alter corneal biomechanical characteristics. In-vivo corneal biomechanical parameters can be evaluated by using Ocular Response Analyzer (ORA). The severity of TED can be identified with a NOSPECS grading system. In this study, corneal biomechanical parameters are compared between patients with TED and healthy group. The NOSPECS classification of patients is also used to identify relation between biomechanical changes and disease severity. Materials and Methods: In this study, 22 patients with thyroid eye disease, diagnosed with thyroid disease for more than five years, and 47 healthy participants were included. All subjects underwent complete endocrinologic and ophthalmologic examination. The NOSPECS classification was assessed and grouped as mild (grade 1-3) and severe (grade 3-6) disease. For each group, corneal hysteresis (CH), corneal resistance factor (CRF), central corneal thickness (CCT), Goldmann-correlated intraocular pressure (IOPg) and corneal compensated intraocular pressure (IOPcc) parameters were measured by Ocular Response Analyzer. Results: The mean age was 38.8+/-11.6 years for the TED patients and 44.6+/-16.0 years for the control group. The mean values of CRF, CH and CCT were measured for the TED patients and healthy participants as following: 10.43+/-2.04 vs 10.16+/-1.90 mmHg, 10.18+/-1.81 vs 10.07+/-1.71 mmHg, and 550.31+/-35.73 vs 543+/-38.39 microm, respectively. These values were not significant between groups, but they were significantly higher in females compared to males in TED patients (p<0.015). CRF values of patients were negatively correlated with NOSPECS score (r=-0.317, p=0.036). Significantly lower CRF was calculated in severe compared to mild disease (p<0.01). Discussion: CRF was significantly increased in female compared to male patients with TED. CRF also showed statistically significant decrease in severe diseases (NOSPECS 3-6) compared to mild diseases (NOSPECS 1-3) and also revealed down treating as disease severity score progresses. CRF might be a reliable parameter to anticipate thyroid eye disease progression during follow-up in clinical practice.
Açıklama
Anahtar Kelimeler
Tiroid Göz Hastalığı, Kornea Biyomekanik Parametreleri, Kornea Direnç Faktörü, NOSPECS Sınıflandırması, Oküler Tepki Analizörü, Thyroid Eye Disease, Corneal Biomechanical Parameters, Corneal Resistance Factor, NOSPECS Classification, Ocular Response Analyzer
Kaynak
Maltepe Üniversitesi Uluslararası Öğrenci Kongresi
WoS Q Değeri
Scopus Q Değeri
Cilt
Sayı
Künye
Comert, M. C., Yılmaz, S. ve Şahin, A. (2019). Tiroid göz hastalığının korneal biyomekanik özellikler üzerine etkisi / The effect of thyroid eye disease on corneal biomechanical properties. Maltepe Üniversitesi Uluslararası Öğrenci Kongresi. s. 79-80.
