The relationship between severity of coronary artery disease and plasma level of vascular endothelial growth factor

Basit Öğe Kaydı
dc.authorid0000-0002-8719-8886en_US
dc.authorid0000-0001-5807-0990en_US
dc.authorid0000-0003-1517-9376en_US
dc.authorid0000-0002-6867-0073en_US
dc.authorid0000-0002-7983-1119en_US
dc.contributor.authorKüçükardalı, Yaşar
dc.contributor.authorAydoğdu, Şebnem
dc.contributor.authorÖzmen, Namık
dc.contributor.authorYonem, Arif
dc.contributor.authorSolmazgül, Emrullah
dc.contributor.authorÖzyurt, Mustafa
dc.contributor.authorAydoğdu, Aydoğan
dc.date.accessioned2024-07-12T21:02:58Z
dc.date.available2024-07-12T21:02:58Z
dc.date.issued2008en_US
dc.departmentFakülteler, Tıp Fakültesien_US
dc.description.abstractObjective It has been known that ischemia or occlusion of coronary arteries in animal models increases the production of vascular endothelial growth factor (VEGF); however, little is known about the relationship between coronary artery disease and VEGF in humans. In this study, our aim was to evaluate the relationships between the degree of coronary occlusion and plasma VEGF level as well as other risk factors, including age, weight, arterial blood pressure, cholesterol, triglyceride, blood glucose, and high-sensitive C-reactive protein (hsCRP) in patients with established coronary artery disease. Materials and Methods Our study group consisted of 77 patients. Of these, 38 patients had normal coronary angiography (control group; group C) and 39 had abnormal angiography (17 critical lesion; group CL, 22 noncritical lesion; non-CL group). Results Plasma VEGF level was 116.95±30.12 pg/ml in the control group, 212.47±75.28 pg/ml in group CL, and 138.89±45.18 pg/ml in the non-CL group. Plasma VEGF level of group C was found to be lower than that of group CL (P<.05), but the difference between groups C and non-CL was insignificant (P>.05). However, logistic regression analysis showed that VEGF level of group CL was significantly higher (P<.001). There was a negative correlation between VEGF and haemoglobin (r=?0.58, P<.01), and positive correlation between VEGF and age (r=0.29, P<.04). There was no relationship between plasma VEGF level and other cardiac risk parameters. Group CL had a higher level of total and LDL-cholesterol levels. Conclusion Increased plasma VEGF levels in patients with coronary artery disease may point that the coronary lesion is critical, and VEGF increase in patients with established coronary artery disease may be used as an indicator of the need for revascularization.en_US
dc.identifier.citationKucukardali, Y., Aydogdu, S., Ozmen, N., Yonem, A., Solmazgul, E., Ozyurt, M., Cingozbay, Y. ve Aydogdu, A. (2008). The relationship between severity of coronary artery disease and plasma level of vascular endothelial growth factor. Cardiovascular revascularization medicine, Elsevier. 9(2), s. 66–70.en_US
dc.identifier.endpage70en_US
dc.identifier.issn1553-8389
dc.identifier.issue2en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage66en_US
dc.identifier.urihttps://linkinghub.elsevier.com/retrieve/pii/S1553-8389(07)00335-1
dc.identifier.urihttps://hdl.handle.net/20.500.12415/3600
dc.identifier.volume9en_US
dc.institutionauthorCingözbay, Bekir Yılmaz
dc.language.isoenen_US
dc.publisherElsevieren_US
dc.relation.ispartofCardiovascular Revascularization Medicineen_US
dc.relation.isversionof10.1016/j.carrev.2007.11.005en_US
dc.relation.publicationcategoryUluslararası Hakemli Dergide Makale - Kurum Öğretim Elemanıen_US
dc.rightsCC0 1.0 Universal*
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.rights.urihttp://creativecommons.org/publicdomain/zero/1.0/*
dc.snmzKY00477
dc.subjectCoronary artery diseaseen_US
dc.subjectSeverityen_US
dc.subjectAngiographyen_US
dc.subjectVEGFen_US
dc.titleThe relationship between severity of coronary artery disease and plasma level of vascular endothelial growth factoren_US
dc.typeArticle
dspace.entity.typePublication

Dosyalar

Koleksiyon

Tıp Fakültesi Koleksiyonu