Lymphocyte-related ratios, systemic immune-inflammatory and systemic inflammatory response index in alcohol use disorder

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dc.contributor.authorKok, Kendirlioglu B.
dc.contributor.authorArat, Celik, H.E.
dc.contributor.authorBuyuksandalyaci, Tunc A.E.
dc.contributor.authorOzmen, M.
dc.contributor.authorCorekli, Kaymakcı E.
dc.contributor.authorDemir, S.
dc.contributor.authorKuçukgoncu, S.
dc.date.accessioned2024-07-12T21:40:21Z
dc.date.available2024-07-12T21:40:21Z
dc.date.issued2024en_US
dc.department[Belirlenecek]en_US
dc.description.abstractAddictive disorders are associated with systemic and central nervous system inflammation, which may be important for the onset and development of these diseases. Although lymphocyte-related parameters have recently been studied in alcohol use disorder (AUD), systemic immune-inflammation index (SII) and systemic inflammatory response index (SIRI) haven’t. Lymphocyte-related ratios, SII and SIRI levels were evaluated between AUD and healthy controls (HC) in this study. It was a retrospective and cross-sectional study. This study included 72 patients with AUD and 184 individuals in the HC group. Lymphocyte related ratios such as neutrophil to lymphocyte ratio (NLR), monocyte to lymphocyte ratio (MLR) and platelet to lymphocyte ratio (PLR), SII and SIRI values were compared. Compared to HC group, NLR (p < 0.001), MLR (p < 0.001), and SIRI (p < 0.001) levels were significantly higher in AUD group. There was also a significant relationship between NLR and AST/ALT ratio in the AUD group (p = 0.022). The results of this study support that AUD is a chronic inflammatory psychiatric disorder. In addition, it may be useful to evaluate these markers in relation to liver enzymes in patients with AUD, as alcohol consumption causes liver damage. These markers may also be used in future studies to assess treatment response and disease severity. © 2023 Taylor & Francis.en_US
dc.description.sponsorshipThe author(s) reported there is no funding associated with the work featured in this article.en_US
dc.identifier.doi10.1080/15321819.2023.2277806
dc.identifier.endpage49en_US
dc.identifier.issn1532-1819
dc.identifier.issue1en_US
dc.identifier.pmid37953614en_US
dc.identifier.scopus2-s2.0-85176724880en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage38en_US
dc.identifier.urihttps://doi.org/10.1080/15321819.2023.2277806
dc.identifier.urihttps://hdl.handle.net/20.500.12415/7263
dc.identifier.volume45en_US
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoenen_US
dc.publisherTaylor and Francis Ltd.en_US
dc.relation.ispartofJournal of Immunoassay and Immunochemistryen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.snmzKY05219
dc.subjectAlcohol Use Disorderen_US
dc.subjectMonocyte-To-Lymphocyte Ratio (Mlr)en_US
dc.subjectNeuroinflammationen_US
dc.subjectNeutrophil-To-Lymphocyte Ratio (Nlr)en_US
dc.subjectSystemic Inflammation Indexen_US
dc.titleLymphocyte-related ratios, systemic immune-inflammatory and systemic inflammatory response index in alcohol use disorderen_US
dc.typeArticle
dspace.entity.typePublication

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