Evaluation of efficacy of immunotherapy in children with asthma monosensitized to Alternaria

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dc.authorid0000-0002-8335-1927en_US
dc.contributor.authorKılıç, Mehmet
dc.contributor.authorAltıntaş, Derya Ufuk
dc.contributor.authorYılmaz, Mustafa
dc.contributor.authorBingöl Karakoç, Gülbin
dc.contributor.authorBurgut, Hüseyin Refik
dc.contributor.authorGüneşer Kendirli, Seval
dc.date.accessioned2024-07-12T21:11:46Z
dc.date.available2024-07-12T21:11:46Z
dc.date.issued2011en_US
dc.departmentFakülteler, Tıp Fakültesien_US
dc.description.abstractIn this study, we aimed to evaluate the efficacy of specific immunotherapy (SIT) in children monosensitized to Alternaria. Sixteen children with bronchial asthma monosensitized to Alternaria were enrolled in the study. Patients were divided into two groups as the immunotherapy group (Group I; 9 patients) and control group (Group II; 7 patients). A significant reduction in bronchial responsiveness to methacholine and Alternaria was found in Group I after one year of SIT (p = 0.03, p = 0.006) in comparison to controls. Specific IgE levels were decreased in the immunotherapy group (p = 0.001). Following allergen provocation, a rise in sputum eosinophil count was found to be lower in the SIT group compared to controls after one year (p = 0.011), and sputum eosinophil cationic protein (ECP) levels did not change in the SIT group, while there was a statistically significant increase in controls. Our results demonstrated that SIT with Alternaria caused clear changes in airway responsiveness and serum-specific IgE levels. However, further long-term studies in large series should be carried out for clinical documentation of the efficacy of SIT in the treatment of children with Alternaria allergy.en_US
dc.identifier.citationKılıç, M., Altıntaş, D. U., Yılmaz, M., Bingöl Karakoç, G., Burgut, H. R., Güneşer Kendirli, S. (2011). Evaluation of efficacy of immunotherapy in children with asthma monosensitized to Alternaria. 53(3), s. 285-294.en_US
dc.identifier.endpage294en_US
dc.identifier.issn0041-4301
dc.identifier.issue3en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage285en_US
dc.identifier.urihttps://pubmed.ncbi.nlm.nih.gov/21980810/
dc.identifier.urihttps://hdl.handle.net/20.500.12415/4397
dc.identifier.volume53en_US
dc.institutionauthorBurgut, Hüseyin Refik
dc.language.isoenen_US
dc.publisherTurkish National Pediatric Societyen_US
dc.relation.ispartofThe Turkish Journal of Pediatricsen_US
dc.relation.publicationcategoryUluslararası Hakemli Dergide Makale - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.snmzKY03576
dc.titleEvaluation of efficacy of immunotherapy in children with asthma monosensitized to Alternariaen_US
dc.typeArticle
dspace.entity.typePublication

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