Serum and follicular fluid levels of soluble Fas, soluble Fas ligand and apoptosis of luteinized granulosa cells in PCOS patients undergoing IVF

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dc.authorid0000-0003-3446-3751en_US
dc.authorid0000-0002-0717-1756en_US
dc.authorid0000-0002-5110-5414en_US
dc.authorid0000-0003-4563-3592en_US
dc.contributor.authorÖnalan, Göğşen
dc.contributor.authorSelam, Belgin
dc.contributor.authorBaran, Yusuf
dc.contributor.authorÖnalan, Reşide
dc.contributor.authorGündüz, Ufuk
dc.contributor.authorUral, Ali Uğur
dc.contributor.authorPabuçcu, Recai
dc.date.accessioned2024-07-12T21:04:05Z
dc.date.available2024-07-12T21:04:05Z
dc.date.issued2005en_US
dc.departmentFakülteler, Tıp Fakültesien_US
dc.description.abstractBACKGROUND: There are limited data about the levels of soluble apoptotic factors and their modulation with therapeutic regimens in IVF cycles. The aim of the current study was to determine follicular fluid, and serum levels of soluble Fas (sFas) and soluble Fas ligand (sFasL) in PCOS patients undergoing IVF/ICSI cycles; also to investigate the effects of metformin on these factors and on apoptosis of luteinized granulosa cells. METHODS: We investigated the serum and follicular fluid levels of sFas and sFasL in patients with PCOS (n=28) and compared them with those of the patients with infertility due to male factor (n=12) undergoing IVF cycles. Effects of metformin therapy on these parameters and apoptosis of luteinized granulosa cells were also investigated among the patients with PCOS. RESULTS: Serum levels of sFas were significantly lower in the PCOS group compared to those in women with infertility due to male factor. Metformin therapy in PCOS patients preceding IVF cycles increased serum levels of sFas and decreased follicular fluid levels of sFasL compared to those on placebo. Follicular fluid from PCOS patients demonstrated luteinized granulosa cell DNA fragmentation in agarose gel, whereas a similar pattern was not observed among PCOS patients undergoing metformin therapy. CONCLUSION: Decreased serum levels of sFas and luteinized granulosa cell DNA fragmentation is observed in patients with PCOS undergoing IVF cycles. Metformin therapy preceding IVF demonstrates an antiapoptotic effect with increased serum levels of sFas, decreased follicular fluid levels of sFasL and prevention of luteinized granulosa cell DNA fragmentation.en_US
dc.identifier.citationOnalan, G., Selam, B., Baran, Y., Cincik, M., Onalan, R., Gündüz, U., Ural, A. U., ve Pabuccu, R. (2005). Serum and follicular fluid levels of soluble Fas, soluble Fas ligand and apoptosis of luteinized granulosa cells in PCOS patients undergoing IVF. Human reproduction, Oxford Academic. 20(9), s. 2391–2395.en_US
dc.identifier.endpage2395en_US
dc.identifier.issn0268-1161
dc.identifier.issn1460-2350
dc.identifier.issue9en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage2391en_US
dc.identifier.urihttps://academic.oup.com/humrep/article/20/9/2391/2356725
dc.identifier.urihttps://hdl.handle.net/20.500.12415/3752
dc.identifier.volume20en_US
dc.institutionauthorCıncık, Mehmet
dc.language.isoenen_US
dc.publisherOxford Academicen_US
dc.relation.ispartofHuman Reproductionen_US
dc.relation.isversionof10.1093/humrep/dei068en_US
dc.relation.publicationcategoryUluslararası Hakemli Dergide Makale - Kurum Öğretim Elemanıen_US
dc.rightsCC0 1.0 Universal*
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.rights.urihttp://creativecommons.org/publicdomain/zero/1.0/*
dc.snmzKY01197
dc.subjectapoptosisen_US
dc.subjectIVFen_US
dc.subjectmetforminen_US
dc.subjectPCOSen_US
dc.subjectsFasen_US
dc.titleSerum and follicular fluid levels of soluble Fas, soluble Fas ligand and apoptosis of luteinized granulosa cells in PCOS patients undergoing IVFen_US
dc.typeArticle
dspace.entity.typePublication

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