Correlation between the mechanical and histological properties of liver tissue

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dc.authorid0000-0003-3411-6215en_US
dc.authorid0000-0002-4899-9146en_US
dc.authorid0000-0002-4474-7371en_US
dc.authorid0000-0002-6382-7334en_US
dc.contributor.authorYarpuzlu, Berkay
dc.contributor.authorAyyıldız, Mehmet
dc.contributor.authorTok, Olgun Enis
dc.contributor.authorGulhan Aktas, Ranan
dc.contributor.authorBasdogan, Cagatay
dc.date.accessioned2024-07-12T21:04:59Z
dc.date.available2024-07-12T21:04:59Z
dc.date.issued2014en_US
dc.departmentFakülteler, Tıp Fakültesien_US
dc.description.abstractIn order to gain further insight into the mechanisms of tissue damage during the progression of liver diseases as well as the liver preservation for transplantation, an improved understanding of the relation between the mechanical and histological properties of liver is necessary. We suggest that this relation can only be established truly if the changes in the states of those properties are investigated dynamically as a function of post mortem time. In this regard, we first perform mechanical characterization experiments on three bovine livers to investigate the changes in gross mechanical properties (stiffness, viscosity, and fracture toughness) for the preservation periods of 5, 11, 17, 29, 41 and 53 h after harvesting. Then, the histological examination is performed on the samples taken from the same livers to investigate the changes in apoptotic cell count, collagen accumulation, sinusoidal dilatation, and glycogen deposition as a function of the same preservation periods. Finally, the correlation between the mechanical and histological properties is investigated via the Spearman's Rank-Order Correlation method. The results of our study show that stiffness, viscosity, and fracture toughness of bovine liver increase as the preservation period is increased. These macroscopic changes are very strongly correlated with the increase in collagen accumulation and decrease in deposited glycogen level at the microscopic level. Also, we observe that the largest changes in mechanical and histological properties occur after the first 11–17 h of preservation.en_US
dc.description.abstractIn order to gain further insight into the mechanisms of tissue damage during the progression of liver diseases as well as the liver preservation for transplantation, an improved understanding of the relation between the mechanical and histological properties of liver is necessary. We suggest that this relation can only be established truly if the changes in the states of those properties are investigated dynamically as a function of post mortem time. In this regard, we first perform mechanical characterization experiments on three bovine livers to investigate the changes in gross mechanical properties (stiffness, viscosity, and fracture toughness) for the preservation periods of 5, 11, 17, 29, 41 and 53 h after harvesting. Then, the histological examination is performed on the samples taken from the same livers to investigate the changes in apoptotic cell count, collagen accumulation, sinusoidal dilatation, and glycogen deposition as a function of the same preservation periods. Finally, the correlation between the mechanical and histological properties is investigated via the Spearman's Rank-Order Correlation method. The results of our study show that stiffness, viscosity, and fracture toughness of bovine liver increase as the preservation period is increased. These macroscopic changes are very strongly correlated with the increase in collagen accumulation and decrease in deposited glycogen level at the microscopic level. Also, we observe that the largest changes in mechanical and histological properties occur after the first 11–17 h of preservation.en_US
dc.identifier.citationYarpuzlu, B., Ayyildiz, M., Tok O. E., Aktas R.G. ve Basdogan C. (2014) Correlation between the Mechanical and Histological Properties of Liver Tissue. Journal of the Mechanical Behavior of Biomedical Materials, Elsevier. 29, s.403-416.en_US
dc.identifier.endpage416en_US
dc.identifier.issn1751-6161
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage403en_US
dc.identifier.urihttps://www.sciencedirect.com/science/article/pii/S1751616113003172?via%3Dihub
dc.identifier.urihttps://hdl.handle.net/20.500.12415/3860
dc.identifier.volume29en_US
dc.language.isoenen_US
dc.publisherElsevieren_US
dc.relation.ispartofJournal of the Mechanical Behavior of Biomedical Materialsen_US
dc.relation.isversionof10.1016/j.jmbbm.2013.09.016en_US
dc.relation.publicationcategoryUluslararası Hakemli Dergide Makale - Kurum Öğretim Elemanıen_US
dc.rightsCC0 1.0 Universal*
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.rights.urihttp://creativecommons.org/publicdomain/zero/1.0/*
dc.snmzKY02067
dc.subjectBovine liveren_US
dc.subjectBovine liveren_US
dc.subjectMaterial characterizationen_US
dc.subjectMaterial characterizationen_US
dc.subjectHyperelasticityen_US
dc.subjectHyperelasticityen_US
dc.subjectViscoelasticityen_US
dc.subjectViscoelasticityen_US
dc.subjectFracture toughnessen_US
dc.subjectFracture toughnessen_US
dc.subjectFinite element modelingen_US
dc.subjectFinite element modelingen_US
dc.subjectHistologyen_US
dc.subjectHistologyen_US
dc.titleCorrelation between the mechanical and histological properties of liver tissueen_US
dc.typeArticle
dspace.entity.typePublication

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