Cystatin C is better than albuminuria as a predictor of pulse wave velocity in hypertensive patients

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dc.contributor.authorOzkok A.
dc.contributor.authorAkpinar T.S.
dc.contributor.authorTufan F.
dc.contributor.authorKaya O.
dc.contributor.authorBozbey H.U.
dc.contributor.authorAtas R.
dc.contributor.authorToz B.
dc.contributor.authorAtay K.
dc.contributor.authorYilmaz E.
dc.contributor.authorBesiroglu M.
dc.contributor.authorNas K.
dc.contributor.authorHadrovic N.
dc.contributor.authorIllyés M.
dc.contributor.authorEcder T.
dc.date.accessioned2024-07-12T21:45:51Z
dc.date.available2024-07-12T21:45:51Z
dc.date.issued2014en_US
dc.departmentMaltepe Üniversitesien_US
dc.description.abstractIntroduction: Arterial stiffness is important in the evaluation of the cardiovascular risk in both general population and hypertensive patients. In this study, we aimed to investigate the associations of both serum cystatin C levels and albuminuria with arterial stiffness in healthy controls and hypertensive patients. Patients and methods: Seventy-six healthy controls (male/female===44/32) and 76 hypertensive patients (male/female===43/33) were enrolled. Arterial stiffness parameters such as augmentation index (AIx) and pulse wave velocity (PWV) were non-invasively measured with the Arteriograph (Tensiomed Ltd., Budapest, Hungary). Results: AIx (31.92=±=14.31 vs. 27.95=±=11.03, p===0.03) and PWV (9.84=±=1.62 vs. 8.87=±=2.04, p=<=0.001) were significantly higher in hypertensive patients compared to healthy controls. Patients with microalbuminuria had significantly higher AIx (43.47=±=9.91 vs. 30.37=±=14.13, p===0.002) and higher serum cystatin C levels [0.76 (0.67-0.95) vs. 0.68 (0.62-0.78) mg/L, p===0.03]. In the hypertensive group, AIx was significantly correlated with PWV (r===0.519, p=<=0.001), glomerular filtration rate (cystatin C) (r===-0.438, p===0.003), mean arterial pressure (MAP) (r===0.288, p===0.015) and urinary albumin-creatinine ratio (ACR) (r===0.386, p===0.004). PWV was associated with serum cystatin C (r===0.442, p===0.003) and MAP (r===0.377, p===0.001). In the linear regression analysis (model r===0.577, p===0.006) for the prediction of PWV in hypertensive patients, MAP, urinary ACR, age and serum cystatin C levels were included as independent variables. Cystatin C was found to be the significant determinant of PWV in hypertensive patients. Conclusion: Multivariate analysis revealed that serum cystatin C but not albuminuria was significantly associated with PWV in hypertensive patients. Serum cystatin C may be better than albuminuria as a predictor of arterial stiffness in hypertensive patients. © 2014 Informa Healthcare USA, Inc. All rights reserved: reproduction in whole or part not permitted.en_US
dc.description.sponsorshipIstanbul Üniversitesi Firat University Scientific Research Projects Management Uniten_US
dc.description.sponsorshipInformed consent was obtained from each patient. The study protocol, which conforms to the ethical guidelines of the Declaration of Helsinki, was approved by the Ethical Committee of Istanbul University (2010/229-37). This study was supported by Istanbul University, Department of Scientific Research Projects (Project no: 4154).en_US
dc.identifier.doi10.3109/10641963.2013.804548
dc.identifier.endpage226en_US
dc.identifier.issn1064-1963
dc.identifier.issue4en_US
dc.identifier.pmid23848132en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage222en_US
dc.identifier.urihttps://dx.doi.org/10.3109/10641963.2013.804548
dc.identifier.urihttps://hdl.handle.net/20.500.12415/7860
dc.identifier.volume36en_US
dc.indekslendigikaynakPubMed
dc.language.isoenen_US
dc.publisherInforma Healthcareen_US
dc.relation.ispartofClinical and Experimental Hypertensionen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.snmzKY00524
dc.subjectAlbuminuriaen_US
dc.subjectArterial stiffnessen_US
dc.subjectAugmentation indexen_US
dc.subjectChronic kidney diseaseen_US
dc.subjectCystatin Cen_US
dc.subjectHypertensionen_US
dc.subjectPulse wave velocityen_US
dc.titleCystatin C is better than albuminuria as a predictor of pulse wave velocity in hypertensive patientsen_US
dc.typeArticle
dspace.entity.typePublication

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