Radikal prostatektomi yapılan hasta verilerinin partin tabloları ile uyumluluğunun araştırılması
Küçük Resim Yok
Tarih
2018
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Maltepe Tıp Dergisi
Erişim Hakkı
Attribution-NonCommercial-NoDerivs 3.0 United States
info:eu-repo/semantics/openAccess
info:eu-repo/semantics/openAccess
Özet
Amaç: Bu çalışmada kliniğimizde radikal prostatektomi operasyonu geçiren prostat kanseri (Pca) hastalarının preoperatif ve postoperatif verilerinin Partin Tabloları ile uyumluluğunu değerlendirmeyi amaçladık. Gereç ve Yöntem: Pca nedeni ile radikal retropubik prostatektomi yapılan ortalama yaşları 66 (47-75) olan 152 hasta çalışmaya dahil edilmiştir. Hastaların preoperatif klinik evreleri, biyopsi Gleason skorları ve total PSA değerleri kaydedilmiştir. Operasyonda çıkarılan pelvik lenf nodları, mikrometastatik kanser varlığı için mikroskopik olarak incelenmiştir. Operasyonda çıkarılan spesimen (prostat ve veziküla seminalis) histolojik inceleme için hazırlanmıştır. Partin Tablosunun kliniğimizdeki hasta grubu verileri ile ilişkisi Receiver Operating Characteristics (ROC) analizi ile değerlendirildi. Bulgular: T1c ve T2a hastalıkta patoloji spesimeninde lenf nodu pozitifliği gözlenmemiştir. T1c hastalık % 64 organ sınırlı iken T2c hastalık % 27 oranında organ sınırlı olarak bulunmuştur. Gleason 6 olan grupta lenf nodu ve seminal vezikül pozitifliği bulunmamaktadır. Gleason 8-10 olan hastalarda organ dışı yayılım % 66 ve lenf nodu pozitifliği % 33’tür. Serum PSA seviyesi 0-2,5 arası hastalar tüm populasyonun % 4’ünü, 2,5- 4 arası olan hastalar % 10’unu ve 4,1-6,0 arası olanlar % 8’ini 6,1-10,0 arası olanlar % 28’ini, 10’un üzerinde olanlar % 50’sini oluşturmaktadır. Area Under Curve (AUC) değerleri ekstra kapsüler yayılım, seminal vezikül tutulumu ve lenf nodu tutulumu için sırası ile 0,674 (p<0,001), 0,741 (p<0,001), 0,842 (p<0,005)’ dir. Sonuç: Mevcut hasta bulgularının, Partin nomogramlarıyla istatistiki olarak uyumluluk sağladığı gözlenmiş ve Partin Tablolarının güncel hasta popülasyonu için de uygulanabilir olduğu sonucuna varılmıştır.
Aims: In this study, we aimed to evaluate the preoperative and postoperative data of patients with prostate cancer (Pca) who underwent radical prostatectomy operations in our clinic and to compare them with the Partin Tables. Materials and Methods: 152 patients with a mean age of 66 (47-75) who underwent radical retropubic prostatectomy for Pca were included in the study. Patients’ preoperative clinical stages, biopsy Gleason scores and total PSA values were recorded. pelvic lymph nodes removed during the operation were examined microscopically for the presence of micrometastatic cancer. Operative specimen (prostate and vesicular seminalis) was prepared for pathological examination. The association of patient’s data with Partin Tables was assessed by Receiver Operating Characteristics (ROC) analysis. Results: In T1c and T2a stage, lymph node positivity was not observed in the pathology specimen. In T1c stage, organ confined disease was 64% whereas in T2c stage organ confined disease was 27%. There is no lymph node and seminal vesicle positivity in the Gleason 6 group. In patients with Gleason 8-10, extracapsular extension is 66% and lymph node positivity is 33%. In the entire population, patients having PSA levels 0-2.5, 2.5-4 and 6.1-10.0 were 4%,10% and 8% respectively. Patients with PSA levels between 4.1- 6.0 were 28%, and those over 10 make up 50%. The Area Under Curve (AUC) values were 0.674 (p <0.001), 0.741 (p <0.001), 0.842 (p <0.005) for extracapsular extension, seminal vesicle involvement and lymph node involvement respectively. Conclusion: Current patient findings were statistically consistent with Partin nomograms, and it was concluded that the Partin Tables are also applicable for updated patient populations.
Aims: In this study, we aimed to evaluate the preoperative and postoperative data of patients with prostate cancer (Pca) who underwent radical prostatectomy operations in our clinic and to compare them with the Partin Tables. Materials and Methods: 152 patients with a mean age of 66 (47-75) who underwent radical retropubic prostatectomy for Pca were included in the study. Patients’ preoperative clinical stages, biopsy Gleason scores and total PSA values were recorded. pelvic lymph nodes removed during the operation were examined microscopically for the presence of micrometastatic cancer. Operative specimen (prostate and vesicular seminalis) was prepared for pathological examination. The association of patient’s data with Partin Tables was assessed by Receiver Operating Characteristics (ROC) analysis. Results: In T1c and T2a stage, lymph node positivity was not observed in the pathology specimen. In T1c stage, organ confined disease was 64% whereas in T2c stage organ confined disease was 27%. There is no lymph node and seminal vesicle positivity in the Gleason 6 group. In patients with Gleason 8-10, extracapsular extension is 66% and lymph node positivity is 33%. In the entire population, patients having PSA levels 0-2.5, 2.5-4 and 6.1-10.0 were 4%,10% and 8% respectively. Patients with PSA levels between 4.1- 6.0 were 28%, and those over 10 make up 50%. The Area Under Curve (AUC) values were 0.674 (p <0.001), 0.741 (p <0.001), 0.842 (p <0.005) for extracapsular extension, seminal vesicle involvement and lymph node involvement respectively. Conclusion: Current patient findings were statistically consistent with Partin nomograms, and it was concluded that the Partin Tables are also applicable for updated patient populations.
Açıklama
Anahtar Kelimeler
Prostat, kanser, Partin, nomogram, prostatektomi, radikal, Prostate, nomograms, radical, prostatectomy
Kaynak
Maltepe Tıp Dergisi
WoS Q Değeri
Scopus Q Değeri
Cilt
10
Sayı
1
Künye
Parlakkılıç, O., Avcı, E., Yılmaz, İ., Salman, Y., Kurtuluş, F. ve Çek, M. (2018). Radikal prostatektomi yapılan hasta verilerinin partin tabloları ile uyumluluğunun araştırılması / Data evaluation in patients undergoing radical prostatectomy in terms of compatibility with partin tables. Maltepe Tıp Dergisi. 10(1), s. 11-15.
