Is there a role for Chlamydia pneumoniae infection in systemic lupus erythematosus and in the associated atherosclerotic cardiovascular disease?

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dc.authorid0000-0002-8505-9137en_US
dc.authorid0000-0003-0374-4841en_US
dc.contributor.authorKitumnuaypong, Tasanee
dc.contributor.authorScalzi, Lisabeth V.
dc.contributor.authorNalbant, Selim
dc.contributor.authorVon feldt, Joan Marie
dc.contributor.authorSchumacher Jr., H. Ralph
dc.date.accessioned2024-07-12T21:03:00Z
dc.date.available2024-07-12T21:03:00Z
dc.date.issued2004en_US
dc.departmentFakülteler, Tıp Fakültesien_US
dc.description.abstractObjective To search for molecular evidence of Chlamydial infection in systemic lupus erythematosus (SLE) subjects and to assess if there is an association of this infectious agent with coronary artery calcification (CAC), a marker of total atherosclerotic burden. Methods 28 SLE subjects had blood samples drawn and DNA extracted from peripheral blood mononuclear cells (PBMC) and an electron beam computed tomography (EBCT) scan. Polymerase chain reaction (PCR) analysis was performed for Chlamydia trachomatis 16srRNA and major outer membrane protein (MOMP) and for C. pneumoniae 16srRNA, MOMP, as well as nested PCR for MOMP. Results Four of 28 subjects (14.2%) had evidence of C. pneumoniae nucleic acid in PBMC. The 16srRNA primers detected C. pneumoniae in one patient (3.57%) and the nested PCR MOMP primers in 3 subjects (10.71%). None were positive for Chlamydia trachomatis. Two of the 4 subjects with C. pneumoniae DNA had abnormal EBCT scans and 2 /11 (18.3%) subjects with abnormal EBCT were positive for C. pneumoniae. There were significant associations of C. pneumoniae DNA with smoking (OR = 3) and corticosteroid use. The odds ratio for subjects with abnormal CAC and detectable C. pneumoniae was 1.67. Conclusion This pilot study demonstrates for the first time that C. pneumoniae DNA can be identified in the PBMC of some SLE subjects and there may be an association with CAC. Smoking may be an additional risk factor for infection in this population. Determination of pathogenicity of this organism in atherosclerotic coronary vascular disease in SLE will require further study.en_US
dc.identifier.citationKitumnuaypong, T., Scalzi, L. V., Nalbant, S., Von feldt, J. M. ve Schumacher Jr., H. R. (2004). Is there a role for Chlamydia pneumoniae infection in systemic lupus erythematosus and in the associated atherosclerotic cardiovascular disease?. Clinical and Experimental Rheumatology, PubMed. 22(3), s. 239-242.en_US
dc.identifier.endpage242en_US
dc.identifier.issn1593-098X
dc.identifier.issn0392-856X
dc.identifier.issue3en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage239en_US
dc.identifier.urihttps://pubmed.ncbi.nlm.nih.gov/15144130/
dc.identifier.urihttps://hdl.handle.net/20.500.12415/3613
dc.identifier.volume22en_US
dc.language.isoenen_US
dc.publisherPubMeden_US
dc.relation.ispartofClinical and Experimental Rheumatologyen_US
dc.relation.publicationcategoryUluslararası Hakemli Dergide Makale - Kurum Öğretim Elemanıen_US
dc.rightsCC0 1.0 Universal*
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.rights.urihttp://creativecommons.org/publicdomain/zero/1.0/*
dc.snmzKY00527
dc.subjectAtherosclerosisen_US
dc.subjectchlamydiaen_US
dc.subjectsystemic lupus erythematosusen_US
dc.titleIs there a role for Chlamydia pneumoniae infection in systemic lupus erythematosus and in the associated atherosclerotic cardiovascular disease?en_US
dc.typeArticle
dspace.entity.typePublication

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