Comparison of integrated positron emission tomography/computed tomography and mediastinoscopy in mediastinal staging of nonsmall cell lung cancer: analysis of 212 patients

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dc.authorid0000-0001-9169-560Xen_US
dc.contributor.authorİskender, İlker
dc.contributor.authorKapıcıbaşı, Hasan Oğuz
dc.contributor.authorKadıoğlu, S. Z.
dc.contributor.authorSevilgen, Gökçen
dc.contributor.authorTezel, Çağatay
dc.contributor.authorKoşar, Altuğ
dc.contributor.authorAtasalihi, A.
dc.contributor.authorKir, An
dc.date.accessioned2024-07-12T21:01:13Z
dc.date.available2024-07-12T21:01:13Z
dc.date.issued2012en_US
dc.departmentFakülteler, Tıp Fakültesien_US
dc.description.abstractBackground : Mediastinal staging is crucial to determine the prognosis and treatment options for patients with non-small cell lung cancer (NSCLC). In this study, we compared the results of integrated positron emission tomography-computerised tomography (PET/CT) with those of mediastinoscopy in mediastinal staging of NSCLC patients. Methods : PET/CT and mediastinoscopy was performed on 250 consecutive patients diagnosed with NSCLC between September 2005 and March 2008. Thirty-eight patients were excluded from the study. Standard cervical mediastinoscopy was performed in all patients, and simultaneous extended cervical mediastinoscopy was performed in 52 patients with left sided lesions. Patients with negative mediastinoscopy underwent resection. The pathological results were correlated with PET/CT findings. Results : A total of 212 patients (199 male, 13 female ; mean age : 58.3 years) were evaluated. In PET/CT analysis 60 true-positive, 45 false-positive, 103 true-negative and 4 false-negative patients were found. The rate of PET/CT positivity of mediastinal lymph nodes was 49.5%. The sensitivity, specificity, positive and negative predictive values and accuracy for PET/CT were 93.8%, 69.6%, 57.1%, 96.3% and 76.9% respectively. The incidence of N2 disease in NSCLC patients with negative mediastinal lymph node uptake on PET/CT was 3.7% (4 of 107). In univariate analysis, right upper lobe tumours were significantly (p < 0.05) more associated with occult N2 disease. Conclusions : In patients with positive mediastinal lymph node uptake on PET/CT invasive mediastinal staging appears necessary for exact staging. Mediastinoscopy can be omitted in NSCLC patients with negative mediastinal uptake on PET/CT in regions where the rate of PET/CT positivity of mediastinal lymph nodes is high.en_US
dc.identifier.citationİskender, I., Kapıcıbaşı, H. O., Kadıoğlu, S. Z., Sevilgen, G., Tezel, C., Koşar, A., Atasalihli, A. ve Kir, A. (2012). Comparison of integrated positron emission tomography/computed tomography and mediastinoscopy in mediastinal staging nonsmall cell lung cancer: Analysis of 212 patients. Acta Chirurgica Belgica. 112, s. 219-225.en_US
dc.identifier.endpage225en_US
dc.identifier.issue112en_US
dc.identifier.startpage219en_US
dc.identifier.urihttps://www.tandfonline.com/doi/abs/10.1080/00015458.2012.11680827
dc.identifier.urihttps://hdl.handle.net/20.500.12415/3470
dc.institutionauthorKoşar, Altuğ
dc.language.isoenen_US
dc.publisherRoyal Belgian Society for Surgeryen_US
dc.relation.ispartofActa Chirurgica Belgicaen_US
dc.relation.publicationcategoryUlusal Hakemli Dergide Makale - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.snmzKY00038
dc.titleComparison of integrated positron emission tomography/computed tomography and mediastinoscopy in mediastinal staging of nonsmall cell lung cancer: analysis of 212 patientsen_US
dc.typeArticle
dspace.entity.typePublication

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