Efficacy of oral Fluconazole in the treatment of seborrheic dermatitis - A placebo-controlled study

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dc.contributor.authorCoemert, Asuman
dc.contributor.authorBekiroglu, Nural
dc.contributor.authorGuerbuez, Oya
dc.contributor.authorErgun, Tuelin
dc.date.accessioned2024-07-12T21:44:32Z
dc.date.available2024-07-12T21:44:32Z
dc.date.issued2007en_US
dc.departmentMaltepe Üniversitesien_US
dc.description.abstractBackground: Seborrheic dermatitis (SD) is a common, chronic dermatosis. Although the pathogenetic mechanisms of SD are not clear, Malassezia spp. yeasts are known to cause the disease. Previous studies have shown that topical and systemic antifungals provide clinical benefit. Objective: To evaluate the safety and efficacy of short-term oral fluconazole in patients with SD. Methods: Sixty-three patients with mild-to-moderate SD were randomly allocated to receive either oral fluconazole 300mg in a single dose per week or placebo, for 2 weeks. Twenty-seven patients taking fluconazole and 23 patients taking placebo completed the study and were analyzed. The SD area severity index (SDASI) score and the patient's subjective assessment of pruritus and burning sensation were evaluated before and after treatment. Both the investigator and the patients were blinded to treatment. Results: A statistically significant improvement in SDASI score after treatment compared with baseline was obtained with fluconazole (p = 0.01) but not with placebo. However, the difference between the treatment groups was not statistically significant (p > 0.05). Subjective improvements in symptoms, such as pruritus and burning sensation, were observed in both groups but no statistically significant differences versus baseline were seen. Conclusion: The results of this study indicate that fluconazole provides marginal and statistically insignificant benefit for the therapy of SD. However, larger studies using different dosages and/or durations of fluconazole therapy may provide a rationale for systemic use of fluconazole in SD.en_US
dc.identifier.endpage238en_US
dc.identifier.issn1175-0561
dc.identifier.issn1179-1888
dc.identifier.issue4en_US
dc.identifier.pmid17645378en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage235en_US
dc.identifier.urihttps://hdl.handle.net/20.500.12415/7735
dc.identifier.volume8en_US
dc.identifier.wosWOS:000248890400005en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakPubMed
dc.language.isoenen_US
dc.publisherADIS INT LTDen_US
dc.relation.ispartofAMERICAN JOURNAL OF CLINICAL DERMATOLOGYen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.snmzKY00162
dc.titleEfficacy of oral Fluconazole in the treatment of seborrheic dermatitis - A placebo-controlled studyen_US
dc.typeArticle
dspace.entity.typePublication

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