Hypersensitivity vasculitis and cytokines

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dc.authorid0000-0002-8719-8886en_US
dc.authorid0000-0002-4936-3705en_US
dc.contributor.authorNalbant, Selim
dc.contributor.authorKoç, Bayram
dc.contributor.authorTop, Cihan
dc.contributor.authorKüçükardalı, Yaşar
dc.contributor.authorBaykal, Yavuz
dc.contributor.authorDanacı, Mehmet
dc.contributor.authorKoçer, İsmail Hakkı
dc.date.accessioned2024-07-12T21:11:02Z
dc.date.available2024-07-12T21:11:02Z
dc.date.issued2002en_US
dc.departmentFakülteler, Tıp Fakültesien_US
dc.description.abstractObjective Hypersensitivity vasculitis (HSV) is secondary vasculitis due to an immune response to exogenous substances. Because of the relative rarity of the vasculitides there are no reports on the role cytokines. This report evaluates some of cytokines which might be involved in pathophysiological events of HSV. Material and methods Patients with HSV (n=20) were classified as active (n=12) ornd inactive (n=8) according to a vasculitis activity index for systemic necrotizing vasculitis (VAI). All the patients were males. A control group was formed from 20 healthy male employees of our department. We performed tests for serum interleukins 6, IL-10, sIL-2 receptor, tumor necrosis factor (TNF) a, C-reactive protein (CRP) levels using enzyme-linked immunosorbent assay and erythrocyte sedimentation rate (ESR). Results The mean ESR value, CRP, and fibrinogen levels were significantly different in both active and inactive HSV from those in the healthy group; they were also significantly higher in the active than in the inactive group. There was no significant difference between healthy and inactive groups for serum IL-10, IL-6, sIL- 2 receptor, and TNFa levels. However, it was also significantly higher for in active HSV patients than in the healthy group. Similar results were obtained comparing active and inactive groups, namely, all cytokine levels were significantly higher for all patients. The most striking finding is the high correlation of ESR also for CRP, fibrinogen) with serum levels of TNFa and IL-10, but not with IL-6 and IL2R. Conclusions These data show that serum TNFa and IL-10 levels can be studied in comparison to traditional markers of inflammation such as sedimentation rate or C-reactive protein. This may lead to new approaches to treating or managing HSV.en_US
dc.identifier.citationNalbant, S., Koç, B., Top, C., Küçükardalı, Y., Baykal, Y., Danacı, M. ve Koçer, İ. H. (2002). Hypersensitivity vasculitis and cytokines. Rheumatology International, PubMed. 22(6), s. 244-248.en_US
dc.identifier.endpage248en_US
dc.identifier.issn0172-8172
dc.identifier.issue6en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage244en_US
dc.identifier.urihttps://pubmed.ncbi.nlm.nih.gov/12426663/
dc.identifier.urihttps://hdl.handle.net/20.500.12415/4321
dc.identifier.volume22en_US
dc.language.isoenen_US
dc.publisherPubMeden_US
dc.relation.ispartofRheumatology Internationalen_US
dc.relation.isversionof10.1007/s00296-002-0235-6en_US
dc.relation.publicationcategoryUluslararası Hakemli Dergide Makale - Kurum Öğretim Elemanıen_US
dc.rightsCC0 1.0 Universal*
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.rights.urihttp://creativecommons.org/publicdomain/zero/1.0/*
dc.snmzKY03365
dc.subjectHypersensitivity vasculitisen_US
dc.subjectInterleukin 6en_US
dc.subjectInterleukin 10en_US
dc.subjectTumor necrosis factor ?en_US
dc.subjectSoluble interleukin 2 receptoen_US
dc.titleHypersensitivity vasculitis and cytokinesen_US
dc.typeArticle
dspace.entity.typePublication

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