The Role of Transforming Growth Factor Beta and Smad Receptors in Determining Prognosis in High-Grade Primary Brain Tumors: Glioblastoma Multiforme

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dc.authoridGürsoy, Güven/0000-0001-8374-7916en_US
dc.authoridGokalp, Sevtap/0000-0002-8615-2448en_US
dc.authoridVatansever, Seda/0000-0002-7415-9618en_US
dc.contributor.authorGürsoy, Güven
dc.contributor.authorBarutcuoğlu, Mustafa
dc.contributor.authorSivrikoz, Oya Nermin
dc.contributor.authorGokalp, Sevtap
dc.contributor.authorVatansever, Seda
dc.date.accessioned2024-07-12T21:37:34Z
dc.date.available2024-07-12T21:37:34Z
dc.date.issued2023en_US
dc.department[Belirlenecek]en_US
dc.description.abstractIntroduction High-grade primary brain tumors cause serious morbidity and mortality. This study aimed to investigate the role of transforming growth factor beta (TGF-beta) and suppressor of mothers against decapentaplegic (Smad) receptors in high-grade primary brain tumors. \Material and Method Thirteen patients with a pathological diagnosis of glioblastoma multiforme were included in the study. Pathological preparations of each patient were analyzed retrospectively in histochemistry and immunohistochemistry laboratories. Transforming growth factor beta 1, TGF-beta 2, TGF-beta 3, Smad 1/2/3, Smad 6, and Smad 7 stainings were evaluated, and the immunoreactivity densities were examined. Result We found out an increase in the expression of TGF-beta 1 and TGF-beta 3 protein. Regarding the inhibitin receptors, Smad 6 showed much more expression than Smad 7. Thus, we found that Smad 6 has a protective effect and role in the tissue. Immunhistochemically, TGF-beta family stains, which are activated by types I-and -II receptors, and the stainless staining of the Smad family might also be showing that the TGF-beta family is taking action with a secondary pathway other than the Smad family. Conclusion In addition to Smad family receptors, Shc-GBR2, SARA, and Ras-Erk1/2 receptors should be investigated in future research. After that, the prognosis, diagnosis, and patient-based chemotherapy strategies for the treatment of glioblastoma multiforme may take a more prominent role.en_US
dc.identifier.doi10.1055/s-0042-1743555
dc.identifier.endpage144en_US
dc.identifier.issn0103-5355
dc.identifier.issn2359-5922
dc.identifier.issue2en_US
dc.identifier.startpage134en_US
dc.identifier.urihttps://doi.org/10.1055/s-0042-1743555
dc.identifier.urihttps://hdl.handle.net/20.500.12415/6850
dc.identifier.volume42en_US
dc.identifier.wosWOS:000892369800001en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Science
dc.language.isoenen_US
dc.publisherGeorg Thieme Verlag Kgen_US
dc.relation.ispartofBrazilian Neurosurgery-Arquivos Brasileiros De Neurocirurgiaen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.snmzKY04192
dc.subjectGlioblastoma Multiformeen_US
dc.subjectTransforming Growth Factor Betaen_US
dc.subjectSmad Proteinsen_US
dc.subjectEndothelial-Mesenchymal Transitionen_US
dc.titleThe Role of Transforming Growth Factor Beta and Smad Receptors in Determining Prognosis in High-Grade Primary Brain Tumors: Glioblastoma Multiformeen_US
dc.typeArticle
dspace.entity.typePublication

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