Comparison of the therapeutic efficacy of 4-methylpyrazole and N-acetylcysteine on acetaminophen (paracetamol) hepatotoxicity in rats

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dc.authorid0000-0003-4170-7865en_US
dc.authorid0000-0002-0603-3896en_US
dc.contributor.authorKüçükardalı, Yaşar
dc.contributor.authorCinan, U
dc.contributor.authorAcar, H. Volkan
dc.contributor.authorÖzkan, Sezai
dc.contributor.authorTop, Cihan
dc.contributor.authorNalbant, Selim
dc.contributor.authorÇermik, Hakan
dc.contributor.authorÇankır, M. Salih Zeki
dc.contributor.authorDanacı, Mustafa
dc.date.accessioned2024-07-12T21:03:08Z
dc.date.available2024-07-12T21:03:08Z
dc.date.issued2002en_US
dc.departmentFakülteler, Tıp Fakültesien_US
dc.description.abstractObtaining effective analgesia with a minimal erosive effect on gastric mucosal tissue has increased the consumption of acetaminophen (paracetamol), especially among the elderly. However, the hepatotoxic effects of acetaminophen have also increased. We aimed to compare the effects of 4-methylpyrazole (4-MP), N-acetylcysteine (NAC) and their combined use on the hepatotoxicity of acetaminophen in a rat model. Male Wistar Albino rats were divided into six groups. Groups 1-5 received 2,000 mg/kg acetaminophen by gavage while the control group was group 6. Group 2 animals were given NAC (loading dose 140 mg/kg followed by seven doses at 4 h intervals); group 3 received 50 mg/kg 4-MP; group 4 received 200mg/kg 4-MP; and group 5 received NAC as in group 2 plus 200 mg/kg 4-MP. Blood samples were taken for measurements of serum AST and ALT levels. The livers of the rats were removed for microscopic examination and grading of hepatic necrosis. AST and ALT levels in groups 2-5 were lower than that of group 1 (p < 0.001), although no significant difference was noted between groups 2-5 (p > 0.05). Higher levels of ALT were found in group 5 than in group 2 (p < 0.05), and higher levels of AST were found in group 5 than in group 3 (p < 0.01). Median necrosis scores were 3.36 for rats receiving acetaminophen alone (p < 0.001, compared with groups 2-6), 1.45-1.81 for groups 2-5 (p > 0.05, compared with each other), and 0.18 for control rats (p < 0.001, compared with groups 1-5). In conclusion, the administration of 4-MP and/or NAC after 4 h of administering toxic dose of acetaminophen, inhibits hepatotoxicity in rats. There was no difference between the 4-MP and NAC-treated groups as reflected by comparable levels of serum transaminases and the degree of hepatic necrosis. Combining of 4-MP and NAC offers no benefit.en_US
dc.identifier.citationKüçükardalı, Y, Cinan, U., Acar, H.V., Özkan, S., Top, C., Nalbant, S., Çermik, H., Çankır, Z. ve Danacı, M. (2002). Comparison of the therapeutic efficacy of 4-methylpyrazole and N-acetylcysteine on acetaminophen (paracetamol) hepatotoxicity in rats. Current Medical Research and Opinion, Taylor & Francis Online. 18(2), s. 78-81.en_US
dc.identifier.endpage81en_US
dc.identifier.issn0300-7995
dc.identifier.issn1473-4877
dc.identifier.issue2en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage78en_US
dc.identifier.urihttps://pubmed.ncbi.nlm.nih.gov/12017214/
dc.identifier.urihttps://hdl.handle.net/20.500.12415/3635
dc.identifier.volume18en_US
dc.language.isoenen_US
dc.publisherTaylor & Francis Onlineen_US
dc.relation.ispartofCurrent Medical Research and Opinionen_US
dc.relation.isversionof10.1185/030079902125000336en_US
dc.relation.publicationcategoryUluslararası Hakemli Dergide Makale - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.snmzKY00586
dc.subject4-Methylpyrazoleen_US
dc.subjectN-Acetylcysteineen_US
dc.subjectAcetaminophenen_US
dc.subjectHepatotoxicityen_US
dc.subjectParacetamolen_US
dc.titleComparison of the therapeutic efficacy of 4-methylpyrazole and N-acetylcysteine on acetaminophen (paracetamol) hepatotoxicity in ratsen_US
dc.typeArticle
dspace.entity.typePublication

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