Perindopril, atenolol, and amlodipine prevent aortic ultrastructural changes in rats exposed to ethanol

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dc.authorid0000-0003-4255-0679en_US
dc.authorid0000-0002-6423-4207en_US
dc.authorid0000-0001-5668-2686en_US
dc.authorid0000-0002-1485-7158en_US
dc.contributor.authorYokuşoğlu, Mehmet
dc.contributor.authorSağ, Cemal
dc.contributor.authorUzun, Mehmet
dc.contributor.authorKayır, Hakan
dc.contributor.authorKöz, Cem
dc.contributor.authorBaykal, Barış
dc.contributor.authorÖzkan, Mustafa
dc.contributor.authorÖzoğul, Candan
dc.contributor.authorBaysan, Oben
dc.contributor.authorUzbay, İsmail Tayfun
dc.date.accessioned2024-07-12T21:10:10Z
dc.date.available2024-07-12T21:10:10Z
dc.date.issued2008en_US
dc.departmentFakülteler, Tıp Fakültesien_US
dc.description.abstractBackground: The effects of perindopril, an angiotensin-converting enzyme inhibitor, atenolol, a beta adrenergic receptor blocker, and amlodipine, a calcium channel blocker, were investigated in chronic alcohol administered rats. Material/methods: Adult male Wistar rats (240-320 g) were used in the present study. Alcohol was given to rats on a modified liquid diet for 21 days. Perindopril (2.5 and 5 mg/kg), atenolol (5 and 10 mg/kg), and amlodipine (5 and 10 mg/kg) were injected into rats in different groups intraperitoneally for 21 days. Control rats were pair fed an isocaloric liquid diet containing sucrose as a caloric substitute for alcohol. Saline was injected into the control rats for 21 days. The hearts were removed after the rats were anesthetized by ether, and 1-mm3 samples from the ascending aortas were fixed. Five fields per aorta were examined and photographed with a transmission electron microscope. Blood alcohol levels were also measured spectrophotometrically. Results: Daily alcohol consumption of the rats was in the range of 12.09-15.50 g/kg. Blood alcohol concentrations were 145.63 mg/dl on the 21st day of alcohol consumption. Chronic alcohol consumption caused some marked aortic wall injuries. Perindopril, atenolol, and amlodipine at high doses, but not low doses, produced some significant beneficial effects on alcohol-induced aortic wall damage. Conclusions: These results imply that perindopril, atenolol, and amlodipine may have protective effects on heavy chronic alcohol consumption-induced aortic wall injury in rats only in high doses.en_US
dc.identifier.citationYokusoglu, M., Sag, C., Cincik, M., Uzun, M., Kayir, H., Koz, C., Baykal, B., Ozkan, M., Ozogul, C., Baysan, O. ve Uzbay, I. T. (2008). Perindopril, atenolol, and amlodipine prevent aortic ultrastructural changes in rats exposed to ethanol. Medical science monitor, International Scientific Information. 14(5), s. 96-102.en_US
dc.identifier.endpage102en_US
dc.identifier.issn1234-1010
dc.identifier.issn1643-3750
dc.identifier.issue5en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage96en_US
dc.identifier.urihttps://pubmed.ncbi.nlm.nih.gov/18443544/
dc.identifier.urihttps://hdl.handle.net/20.500.12415/4198
dc.identifier.volume14en_US
dc.institutionauthorCıncık, Mehmet
dc.language.isoenen_US
dc.publisherInternational Scientific Informationen_US
dc.relation.ispartofMedical Science Monitoren_US
dc.relation.publicationcategoryUluslararası Hakemli Dergide Makale - Kurum Öğretim Elemanıen_US
dc.rightsCC0 1.0 Universal*
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.rights.urihttp://creativecommons.org/publicdomain/zero/1.0/*
dc.snmzKY02898
dc.titlePerindopril, atenolol, and amlodipine prevent aortic ultrastructural changes in rats exposed to ethanolen_US
dc.typeArticle
dspace.entity.typePublication

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