Anti?HCV and HCV?RNA prevalence and clinical correlations in cases with non?Hodgkin's lymphoma

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dc.authorid0000-0002-8335-1927en_US
dc.contributor.authorPaydaş, Semra
dc.contributor.authorKılıç, Banu
dc.contributor.authorYavuz, Sinan
dc.contributor.authorDisel, Umut
dc.contributor.authorTanrıverdi, Kahraman
dc.contributor.authorŞahin, Berksoy
dc.contributor.authorBurgut, Hüseyin Refik
dc.date.accessioned2024-07-12T21:01:26Z
dc.date.available2024-07-12T21:01:26Z
dc.date.issued2003en_US
dc.departmentFakülteler, Tıp Fakültesien_US
dc.description.abstractHepatitis C virus (HCV) is an RNA virus in the Flaviviridae family. It displays lymphotropism in addition to hepatotropism and extrahepatic manifestations are very well known. There are many studies showing an association between HCV infection and non?Hodgkin's lymphomas (NHL). In this study the evidence for HCV infection was studied in cases with NHL. To this end, anti?HCV antibody and HCV?RNA were screened in serum samples of cases with NHL using third?generation ELISA and RT?PCR. Anti?HCV antibody was studied in 223 patients and was found to be positive in 18 cases (8.1%). Anti?HCV antibody positivity was compared with our blood bank / blood donor population. There was an important increased risk of HCV infection—the common odds ratio was 34.56 and corrected odds ratio was 19.07. HCV?RNA was studied in 67 of 223 serum samples. HCV?RNA was found to be positive in 21 of 67 samples (31.3%). When compared with clinico?demographic parameters for anti?HCV and HCV?RNA, including age, nodal status, and grade (in evaluable cases), except age in cases with or without HCV?RNA, we did not find an important correlation with HCV status and clinical findings (P = 0.155; 0.442; 0.288 for anti?HCV and 0.027; 0,558; 0.126, respectively). These results suggest that HCV infection may be an important risk factor for lymphomagenesis and HCV?RNA is more useful for the detection of HCV infection in these immunosuppressed cases. Simultaneous detection of anti?HCV and HCV?RNA will be more informative in this population.en_US
dc.identifier.citationPaydaş, S., Kılıç, B., Yavuz, S., Disel, U., Tanrıverdi, K., Şahin, B. ve Burgut, H. R. (2003). Anti?HCV and HCV?RNA prevalence and clinical correlations in cases with non?Hodgkin's lymphoma. American Journal of Hematology. 74(2), s. 89-93.en_US
dc.identifier.endpage93en_US
dc.identifier.issue2en_US
dc.identifier.startpage89en_US
dc.identifier.urihttps://onlinelibrary.wiley.com/doi/abs/10.1002/ajh.10386
dc.identifier.urihttps://hdl.handle.net/20.500.12415/3503
dc.identifier.volume74en_US
dc.institutionauthorBurgut, Hüseyin Refik
dc.language.isoenen_US
dc.publisherWiley Online Libraryen_US
dc.relation.ispartofAmerican Journal of Hematologyen_US
dc.relation.isversionof10.1002/ajh.10386en_US
dc.relation.publicationcategoryUluslararası Hakemli Dergide Makale - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.snmzKY00168
dc.titleAnti?HCV and HCV?RNA prevalence and clinical correlations in cases with non?Hodgkin's lymphomaen_US
dc.typeArticle
dspace.entity.typePublication

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