Serum paraoxonase- 1 activity in children: The effects of obesity and insulin resistance

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dc.contributor.authorAgirbasli M.
dc.contributor.authorTanrikulu A.
dc.contributor.authorErkus E.
dc.contributor.authorAzizy M.
dc.contributor.authorAcar Sevim B.
dc.contributor.authorKaya Z.
dc.contributor.authorTaskin A.
dc.contributor.authorAksoy N.
dc.contributor.authorDemirbag R.
dc.date.accessioned2024-07-12T21:44:14Z
dc.date.available2024-07-12T21:44:14Z
dc.date.issued2014en_US
dc.departmentMaltepe Üniversitesien_US
dc.description.abstractOxidative stress (OS) is important in the pathogenesis of atherosclerosis. Paraoxonase-1 (PON1) is an enzyme found in the circulation associated with high-density lipoprotein (HDL). HDL-associated enzyme PON1 has an important role in the attenuation of atherogenic low-density lipoprotein (LDL) oxidation. The aim of this study was to determine PON1 and arylesterase (AREST) enzyme levels in relation to insulin resistance (IR) or obesity among children and adolescents. The study included healthy school children and adolescents. Blood was drawn for the determination of blood glucose, lipid, PON1 and AREST enzyme levels. Overall, we observed a positive correlation between PON1 enzyme activity and high-density lipoprotein cholesterol (HDL-C) levels (r = 0.189, P = 0.014). The correlation appeared to be more significant in boys (r = 0.271, P = 0.009). For subjects with IR and obesity, PON1 enzyme activity did not correlate with HDL-C levels (r = 0.038, P = 0.790), instead PON1 levels correlated negatively with BMI (r = - 0.309 and P = 0.026). Multiple linear regression analysis was performed to find the predictors of log PON1 activity. HDL-C level was the strongest predictor of PON1 activity in the lean control group, while BMI appeared to be the strongest predictor in the subjects with obesity or IR. In conclusion, determinants of PON1 enzyme activity are variable in children and adolescents based on IR and obesity. Future studies will shed light on the underlying mechanisms and biomarkers of OS in children and may reveal possible targets for therapeutic intervention. © 2014, Acta Cardiologica. All rights reserved.en_US
dc.identifier.doi10.2143/AC.69.6.1000011
dc.identifier.endpage685en_US
dc.identifier.issn0001-5385
dc.identifier.issue6en_US
dc.identifier.pmid25643439en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage679en_US
dc.identifier.urihttps://dx.doi.org/10.2143/AC.69.6.1000011
dc.identifier.urihttps://hdl.handle.net/20.500.12415/7701
dc.identifier.volume69en_US
dc.indekslendigikaynakPubMed
dc.language.isoenen_US
dc.publisherActa Cardiologicaen_US
dc.relation.ispartofActa Cardiologicaen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.snmzKY00029
dc.subjectChildrenen_US
dc.subjectHDL-Cen_US
dc.subjectInsulin resistanceen_US
dc.subjectOxidative stressen_US
dc.subjectParaoxonaseen_US
dc.titleSerum paraoxonase- 1 activity in children: The effects of obesity and insulin resistanceen_US
dc.typeArticle
dspace.entity.typePublication

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