Effects of sodium valproate on renal functions in rats

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dc.authorid0000-0002-8335-1927en_US
dc.contributor.authorHergüner, Özlem
dc.contributor.authorAltunbaşak, Şakir
dc.contributor.authorDoğan, Ayşe
dc.contributor.authorYıldızdaş, Dinçer
dc.contributor.authorİncecik, Faruk
dc.contributor.authorErdoğan, Şeyda
dc.contributor.authorGönlüşen, Gülfiliz
dc.date.accessioned2024-07-12T21:11:01Z
dc.date.available2024-07-12T21:11:01Z
dc.date.issued2006en_US
dc.departmentFakülteler, Tıp Fakültesien_US
dc.description.abstractIn recent years, it has been reported that sodium valproate occasionally can cause renal tubular impairment. This study was designed to demonstrate the renal tubular and glomerular functions in rats given sodium valproate as monotherapy, as well as to determine any reversibility of dysfunctions. Female rats were randomly allocated to three groups: group 1 received sodium valproate 500 mg/kg/d intraperitoneal for six weeks; after the same injection period, group 2 was housed for another six weeks, after which laboratory investigations were completed; and group 3 served as a control group made up of 20 healthy rats living in same condition without any treatment. Serum ALT, total protein, uric acid, ALP, phosphorus, sodium levels, and urine Ca/cr ratio were significantly different between groups 1 and 3 ( p < 0.025), but this difference was not seen between groups 2 and 3. On the other hand, other parameters such as TRP, Ccr, NAG, and MDA were not significantly different among the three groups ( p > 0.025) These results suggest that SV does not have a significant dose- or time-related side effect on renal functions. Minor biochemical dysfunctions related to long-term sodium valproate therapy is reversible, and the minimal renal fibrosis that showed histopathologically is not clinically important. The renal tissues of rats are known to show similar metabolic and histological patterns with human renal tissues. No renal dysfunction was expected in humans because there were no clinically statistically significant renal side effects in this study.en_US
dc.identifier.citationHergüler, M. Ö., Altunbaşak, Ş., Doğan, A., Yıldızdaş, D., İncecik, F., Erdoğan, Ş., Gönlüşen, G., Dağlıoğlu, K., Dikmen, N. ve Burgut, H. R. (2006). Effects of sodium valproate on renal functions in rats. Renal Failure Journal. 28, s. 593-597.en_US
dc.identifier.endpage597en_US
dc.identifier.issn1525-6049
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage593en_US
dc.identifier.urihttps://hdl.handle.net/20.500.12415/4316
dc.identifier.volume28en_US
dc.institutionauthorBurgut, Hüseyin Refik
dc.language.isoenen_US
dc.publisherTaylor and Francis Onlineen_US
dc.relation.ispartofRenal Failure Journalen_US
dc.relation.isversionof10.1080/08860220600843821en_US
dc.relation.publicationcategoryUluslararası Hakemli Dergide Makale - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.snmzKY03338
dc.subjectRenal functionsen_US
dc.subjectRatsen_US
dc.subjectSodium valproateen_US
dc.titleEffects of sodium valproate on renal functions in ratsen_US
dc.typeArticle
dspace.entity.typePublication

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