Total cholesterol-to-high-density lipoprotein cholesterol ratio predicts high-sensitivity C-reactive protein levels in Turkish children
| dc.contributor.author | Agirbasli M. | |
| dc.contributor.author | Tanrikulu A. | |
| dc.contributor.author | Acar Sevim B. | |
| dc.contributor.author | Azizy M. | |
| dc.contributor.author | Bekiroglu N. | |
| dc.date.accessioned | 2024-07-12T21:50:39Z | |
| dc.date.available | 2024-07-12T21:50:39Z | |
| dc.date.issued | 2015 | en_US |
| dc.department | Maltepe Üniversitesi | en_US |
| dc.description.abstract | Background High-sensitivity C-reactive protein (hs-CRP) is a biomarker of continued long-term systemic inflammation and cardiovascular (CV) risk. Objective To analyze the association of hs-CRP levels with CV risk factors in healthy school children. Methods The study sample was derived from a survey on the prevalence of CV risk factors (dyslipidemia, obesity, high blood pressure, and insulin resistance in school children. Along with anthropometry, hs-CRP levels, lipids, glucose levels, and insulin levels were measured. Results Ninety-one male (12.5 ± 3.4 years) and 77 female students (12.7 ± 3.4; P =.624) were included. Median (interquartile range) hs-CRP levels were similar among boys and girls (0.4 [1.2] vs 0.5 [0.7]; P =.928). Risk factors such as obesity (16%), high triglycerides (20%), low high-density lipoprotein cholesterol (HDL-C, 16%), and elevated blood pressure (25%) were commonly observed in study participants. Gender-stratified analysis displayed that insulin resistance (18 [19.8%] vs 3 [3.9%]; P =.002) and high triglycerides (26 [28.6%] vs 8 [10.4%]; P =.003) were more commonly observed among boys compared with girls. hs-CRP levels correlated positively with cardiometabolic risk factors such as waist circumference (boys) and total cholesterol (TC)-to-HDL-C ratio. Linear regression analysis displayed that among the covariates of age, body mass index, and glucose, TC-to-HDL-C ratio was the most significant determinant of hs-CRP levels (P =.004). Conclusion Cardiometabolic risk factors such as TC-to-HDL-C ratio correlate with hs-CRP levels in children and adolescents. Long-term prospective studies are needed to confirm the association between hs-CRP and cardiometabolic risk in children. © 2015 National Lipid Association. | en_US |
| dc.identifier.doi | 10.1016/j.jacl.2014.12.010 | |
| dc.identifier.endpage | 200 | en_US |
| dc.identifier.issn | 1933-2874 | |
| dc.identifier.issue | 2 | en_US |
| dc.identifier.pmid | 25911075 | en_US |
| dc.identifier.scopusquality | Q1 | en_US |
| dc.identifier.startpage | 195 | en_US |
| dc.identifier.uri | https://dx.doi.org/10.1016/j.jacl.2014.12.010 | |
| dc.identifier.uri | https://hdl.handle.net/20.500.12415/8172 | |
| dc.identifier.volume | 9 | en_US |
| dc.indekslendigikaynak | PubMed | |
| dc.language.iso | en | en_US |
| dc.publisher | Elsevier Ltd | en_US |
| dc.relation.ispartof | Journal of Clinical Lipidology | en_US |
| dc.relation.publicationcategory | Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı | en_US |
| dc.rights | info:eu-repo/semantics/closedAccess | en_US |
| dc.snmz | KY01853 | |
| dc.subject | C-reactive protein | en_US |
| dc.subject | Cardiometabolic risk | en_US |
| dc.subject | Children | en_US |
| dc.subject | TC-to-HDL-C ratio | en_US |
| dc.title | Total cholesterol-to-high-density lipoprotein cholesterol ratio predicts high-sensitivity C-reactive protein levels in Turkish children | en_US |
| dc.type | Article | |
| dspace.entity.type | Publication |
