Effects of phototherapy on newborn rat testicles

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dc.authorid0000-0002-7231-0257en_US
dc.authorid0000-0002-0717-1756en_US
dc.authorid0000-0001-5668-2686en_US
dc.contributor.authorÇetinkurşun, S.
dc.contributor.authorDemirbağ, S.
dc.contributor.authorBaykal, Barış
dc.contributor.authorGünal, A.
dc.date.accessioned2024-07-12T21:01:59Z
dc.date.available2024-07-12T21:01:59Z
dc.date.issued2006en_US
dc.departmentFakülteler, Tıp Fakültesien_US
dc.description.abstractPhototherapy is the most widespread treatment for lowering bilirubin concentration in neonates. In the routine, phototherapy has some side effects including skin eruption, fluid loss, abdominal distention, mild hemolysis and mild thrombocytopenia. The aim of the study was to investigate the possible mutagenic and gametocidal side effects of 72 h continuous phototherapy on the rat testicle. We observed decreases in spermatogonia numbers per tubule (S/T values), tubular fertilization index (TFI) and sperm sertoli cell index (SSCI), which are the most reliable methods in estimating future fertility potential, due to sensitivity to phototherapy. The differences between study and control groups for S/T, TFI and SSCI values were statistically significant (p = 0.008, p = 0.02 and p = 0.004, respectively). There were significant differences in seminiferous tubule diameters between the control and study groups (p < 0.005), but no significant difference in DNA index values between the control (0.66 +/- 0.12) and study (0.59 +/- 0.05) groups (p > 0.05). As a conclusion, phototherapy seems to have some side effects on the newborn rat testicle. Further studies with larger groups, designed for investigation of the effects of phototherapy on seminiferous tubules, may give more beneficial results.en_US
dc.identifier.citationCetinkursun, S., Demirbag, S., Cincik, M., Baykal, B., & Gunal, A. (2006). Effects of phototherapy on newborn rat testicles. Archives of andrology, Taylor and francis Online. 52(1), s. 61–70.en_US
dc.identifier.endpage70en_US
dc.identifier.issn1939-6368
dc.identifier.issn1939-6376
dc.identifier.issue1en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage61en_US
dc.identifier.urihttps://pubmed.ncbi.nlm.nih.gov/16338871/
dc.identifier.urihttps://hdl.handle.net/20.500.12415/3553
dc.identifier.volume52en_US
dc.institutionauthorCıncık, Mehmet
dc.language.isoenen_US
dc.publisherTaylor and Francis Onlineen_US
dc.relation.ispartofArchives of Andrologyen_US
dc.relation.isversionof10.1080/01485010500302089en_US
dc.relation.publicationcategoryUluslararası Hakemli Dergide Makale - Kurum Öğretim Elemanıen_US
dc.rightsCC0 1.0 Universal*
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.rights.urihttp://creativecommons.org/publicdomain/zero/1.0/*
dc.snmzKY00333
dc.titleEffects of phototherapy on newborn rat testiclesen_US
dc.typeArticle
dspace.entity.typePublication

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