Demyelinating Disease of the Central Nervous System Concurrent With COVID-19

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Date

2021

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Volume Title

Publisher

Cureus Inc

Access Rights

info:eu-repo/semantics/openAccess

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Abstract

Neurological diseases related to coronavirus disease-2019 (COVID-19) are increasingly reported. We report here three cases that presented with subtle neurologic findings manifesting within a range of 15 days to four months after their COVID-19 diagnoses. Magnetic resonance imaging showed acute multifocal periventricular and subcortical demyelinating lesions. Some of the lesions showed contrast enhancement and diffusion restriction. Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) PCR was found in the cerebrospinal fluid of just one patient. All patients received intravenous methylprednisolone therapy. In this report, we aim to discuss the aspects of possible COVID-19-related demyelination that support a diagnosis of multiple sclerosis (MS) or acute disseminated encephalomyelitis (ADEM).

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Keywords

Covid-19, Demyelinating Disease, Multiple Sclerosis, Adem, Demiyelination

Journal or Series

Cureus Journal of Medical Science

WoS Q Value

N/A

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Volume

13

Issue

8

Citation