Servikal sitoloji anormalliğinde human papilloma virus ile endoservikal örnekleme prevalansının araştırılması–vaka kontrol çalışması / Investigation of the prevalence of human papilloma virus and endocervical sampling in cervical cytology abnormalities–case-control study
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Tarih
2022
Yazarlar
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Maltepe Üniversitesi
Erişim Hakkı
info:eu-repo/semantics/openAccess
Özet
Amaç: Servikal kanser dördüncü sıklıkta görülen ve önlenebilir bir kanserdir. Bu nedenle birçok tarama programı geliştirilmiştir. Çalışmamızda anormal servikal sitolojide anormal endoservikal patoloji ve Human Papilloma Virus (HPV) prevalansını ve endoservikal örneklemenin önemini saptamayı amaçlamış bulunmaktayız. Materyal ve Metodlar: Çalışmamız Ocak 2013 ve Nisan 2016 tarihleri arasında Aydın Adnan Menderes Üniversitesi Hastanesinde yapılmıştır. Çalışmamız HPV DNA bakılmış ve endoservikal küretaj ile örneklem yapılmış hastalar üzerinde yapılmıştır. Servikal sitoloji anormalliği olan 215 hasta ile 175 kontrol grubu mevcuttur. Servikal sitoloji Bethesda 2001 sınıflandırma sistemine göre yorumlanmıştır. İstatiksel analiz SPSS 22.0 for Windows programı ile yapılmıştır. Bulgular: Çalışmamızda 390 hasta üzerinde yapılmıştır. 215 (%55) hastada anormal Pap smear, 175 (%45) hastada normal Pap smear saptanmıştır. Olguların ortalama yaşı 45.5±9’dur. Anormal Pap smearli olgularda HPV pozitifliği prevalansı %68.8, endoservikal örneklem patoloji prevalansı %40 olarak saptandı. Kontrol grubunda HPV pozitifliği prevalansı %53.7 idi. Endoservikal örneklem sonucu anormal olan hastaların prevalansı %2.8 idi. Anormal smear sitolojisi ile HPV DNA pozitifliği arasında istatistiksel olarak anlamlı ilişki saptandı (p=0.002). Servikal sitoloji anormalliği ile anormal endoservikal örnekleme patoloji sonuçları arasında istatistiksel olarak anlamlı ilişki saptandı (p?0.001). Servikal sitoloji anormalliğinin derecesi arttıkça endoservikal örneklem anormallikleri ve HPV DNA pozitifliğinin sıklığında artma olduğu görüldü (p=0.002). Sonuc: HPV pozitifliği servikal sitoloji anormalliği ile ilişkili bulunmuştur. Anormal servikal sitoloji ile anormal endoservikal patoloji arasında anlamlı ilişki bulunmuştur. Servikal sitoloji anormalliğinin derecesi arttıkça endoservikal örneklem anormallikleri ve HPV DNA pozitifliğinin sıklığında artma olduğu saptanmıştır.
Aim: Cervical cancer is the fourth most common cancer and is preventable Therefore, many screening programs have been developed. In our study, we aimed to determine the prevalence of abnormal endocervical pathology and Human Papilloma Virus (HPV) in abnormal cervical cytology, and the importance of endocervical sampling. Material and Methods: Our study was carried out at Aydın Adnan Menderes University Hospital between January 2013 and April 2016. Our study was carried out on patients whose HPV DNA was examined and sampled by endocervical curettage. There were 215 patients with cervical cytology abnormalities and 175 controls. Cervical cytology was interpreted according to the Bethesda 2001 classification system. Statistical analysis was done with SPSS 22.0 for Windows program. Results: Our study was conducted on 390 patients. Abnormal Pap smear was found in 215 (55%) patients, and normal Pap smear was found in 175 (45%) patients. The mean age of the cases was 45.5±9 years. The prevalence of HPV positivity in cases with abnormal Pap smear was 68.8%, and the prevalence of endocervical sample pathology was 40%. The prevalence of HPV positivity in the control group was 53.7%. The prevalence of patients with abnormal endocervical sampling results was 2.8%. A statistically significant correlation was found between abnormal smear cytology and HPV DNA positivity (p=0.002). A statistically significant correlation was found between cervical cytology abnormality and abnormal endocervical sampling pathology results (p?0.001). As the degree of cervical cytology abnormality increased, it was observed that the frequency of endocervical sample abnormalities and HPV DNA positivity increased (p=0.002). Conclusion: HPV positivity was found to be associated with cervical cytology abnormality. A significant correlation was found between abnormal cervical cytology and abnormal endocervical pathology. As the degree of cervical cytology abnormality increased, it was determined that the frequency of endocervical sample abnormalities and HPV DNA positivity increased.
Aim: Cervical cancer is the fourth most common cancer and is preventable Therefore, many screening programs have been developed. In our study, we aimed to determine the prevalence of abnormal endocervical pathology and Human Papilloma Virus (HPV) in abnormal cervical cytology, and the importance of endocervical sampling. Material and Methods: Our study was carried out at Aydın Adnan Menderes University Hospital between January 2013 and April 2016. Our study was carried out on patients whose HPV DNA was examined and sampled by endocervical curettage. There were 215 patients with cervical cytology abnormalities and 175 controls. Cervical cytology was interpreted according to the Bethesda 2001 classification system. Statistical analysis was done with SPSS 22.0 for Windows program. Results: Our study was conducted on 390 patients. Abnormal Pap smear was found in 215 (55%) patients, and normal Pap smear was found in 175 (45%) patients. The mean age of the cases was 45.5±9 years. The prevalence of HPV positivity in cases with abnormal Pap smear was 68.8%, and the prevalence of endocervical sample pathology was 40%. The prevalence of HPV positivity in the control group was 53.7%. The prevalence of patients with abnormal endocervical sampling results was 2.8%. A statistically significant correlation was found between abnormal smear cytology and HPV DNA positivity (p=0.002). A statistically significant correlation was found between cervical cytology abnormality and abnormal endocervical sampling pathology results (p?0.001). As the degree of cervical cytology abnormality increased, it was observed that the frequency of endocervical sample abnormalities and HPV DNA positivity increased (p=0.002). Conclusion: HPV positivity was found to be associated with cervical cytology abnormality. A significant correlation was found between abnormal cervical cytology and abnormal endocervical pathology. As the degree of cervical cytology abnormality increased, it was determined that the frequency of endocervical sample abnormalities and HPV DNA positivity increased.
Açıklama
Anahtar Kelimeler
Anormal smear, endoservikal örnekleme, HPV, serviks kanseri, Abnormal smear, cervical cancer, endocervical sampling, HPV
Kaynak
Maltepe Tıp Dergisi
WoS Q Değeri
Scopus Q Değeri
Cilt
14
Sayı
2
Künye
Kaplan, İ. (2022). Servikal sitoloji anormalliğinde human papilloma virus ile endoservikal örnekleme prevalansının araştırılması–vaka kontrol çalışması / Investigation of the prevalence of human papilloma virus and endocervical sampling in cervical cytology abnormalities–case-control study. Maltepe Tıp Dergisi, Maltepe Üniversitesi. 14(2), s. 37-42.
