Sternal cyanoacrylate gluing in mediastinitis - Effects on infection, stability and bone healing
Küçük Resim Yok
Tarih
2002
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
EDIZIONI MINERVA MEDICA
Erişim Hakkı
info:eu-repo/semantics/closedAccess
Özet
Background It is crucial to determine stability, histocompatibility and antibacterial properties of the cyanoacrylate used for sternal fixation. Methods. Clinical study: in 17 cases of mediastinitis, debridement and rewiring the sternum, was applied as the treatment method (Group I). Eighteen cases of mediastinitis were treated with the same method added sternal cyanoacrylate gluing (Group 11). A comparative study was done;, the follow-up period was 36.7 +/- 4 and 18.5 +/- 6.9 months in Group I and H, respectively. Animal study: in 10 rats, upper sternotomy was done and the sternal bone was contaminated. Direct wound closure was done in 4 rats (Group A), in 6 animals, wounds were dosed after applying cyanoacrylate in sternal split (Group B). in this prospective study, all rats alive were sacrificed at the 3rd and 8th weeks and sternums were examined histologically. Results. Clinical study: in Group 1, 6 patients required additional interventions due to recurrent sternal detachment and osteomyelitis (35.3%). In Group H neither osteomyelitis nor sternal detachment occurred, 3 patients required re-intervention related to cyanoacrylate histotoxicity. Hospital stay was higher in Group I than Group II (24.06 +/- 4.7 vs 14.16 +/- 3.98 days, respectively). Experimental study: all of the animals in Group A died of sepsis. In Group B all rats survived the procedure. At the 3rd week histologic evaluations showed that cyanoacrylate was not degraded, and no infection or foreign body reaction was observed. At the 8th week histologic examination showed that cyanoacrylate was completely degraded and replaced by connective tissue. Conclusions. Cyanoacrylate is effective in diminishing sternal wound complications and related cost and hospital stay of mediastinitis.
Açıklama
Anahtar Kelimeler
cyanoacrylates, biocompatible materials, osteomyelitis, mediastinitis, surgery, sternum, surgery
Kaynak
JOURNAL OF CARDIOVASCULAR SURGERY
WoS Q Değeri
Q3
Scopus Q Değeri
Q2
Cilt
43
Sayı
5
