Role of homocysteine for thromboembolic complication in patients with non-valvular atrial fibrilation
dc.authorid | 0000-0002-2858-4023 | en_US |
dc.authorid | 0000-0003-1407-5313 | en_US |
dc.contributor.author | Yiğiner, Ömer | |
dc.contributor.author | Cebeci, Bekir Sıtkı | |
dc.contributor.author | Kardeşoğlu, Ejder | |
dc.contributor.author | Demiralp, E. | |
dc.contributor.author | Dinçtürk, Mehmet | |
dc.date.accessioned | 2024-07-12T21:02:09Z | |
dc.date.available | 2024-07-12T21:02:09Z | |
dc.date.issued | 2002 | en_US |
dc.department | Fakülteler, Tıp Fakültesi | en_US |
dc.description.abstract | Thromboembolism is the most important complication in patients with atrial fibrilation (AF). Homocysteine is a toxic amino acid that has been recently accepted as a risk factor for atherosclerosis and stroke. The aim of the present study is to show whether there is a relation between hyperhomocysteinemia and thromboembolic complications in patients with non-valvular AF. We admitted 38 patients with non-valvular AF. The patients were divided into two groups: group A (n = 20; mean age, 75.7 +/- 10.4 years; three males/17 females), and group B (n = 18; mean age, 68.0 +/- 10.6 years; 11 males/seven females). While group A consisted of the patients with AF and stroke, group B was composed of the patients with AF but without stroke. The patients having sinus rhythm (15 subjects) were used as the reference group to obtain the cut-off value. Homocysteine was measured by the immunoassay method. The means of the homocysteine levels were 12.4 +/- 3.3 micromol/l in group A, 8.3 +/- 2.3 micromol/l in group B and 9.3 +/- 1.8 micromol/l in the reference group. The cut-off value was 10.6 micromol/l. Group A had a statistically higher homocysteine level than not only group B, but also the reference group (P < 0.05). While 60% of group A (n = 12) had the elevated homocysteine level, the rate was only 22% for group B (n = 4). In conclusion, hyperhomocysteinemia may be one of the explanations for the increased rate of thromboembolic complications in older patients with AF. | en_US |
dc.identifier.citation | Cingozbay, B. Y., Yiginer, O., Cebeci, B. S., Kardesoglu, E., Demiralp, E. ve Dincturk, M. (2002). Role of homocysteine for thromboembolic complication in patients with non-valvular atrial fibrilation. Blood coagulation & fibrinolysis, Wolters Kluwer Health. 13(7), s. 609–613. | en_US |
dc.identifier.endpage | 613 | en_US |
dc.identifier.issn | 0957-5235 | |
dc.identifier.issn | 1473-5733 | |
dc.identifier.issue | 7 | en_US |
dc.identifier.scopusquality | Q3 | en_US |
dc.identifier.startpage | 609 | en_US |
dc.identifier.uri | https://journals.lww.com/bloodcoagulation/Fulltext/2002/10000/Role_of_homocysteine_for_thromboembolic.5.aspx | |
dc.identifier.uri | https://hdl.handle.net/20.500.12415/3587 | |
dc.identifier.volume | 13 | en_US |
dc.institutionauthor | Cingözbay, Bekir Yılmaz | |
dc.language.iso | en | en_US |
dc.publisher | Wolters Kl | en_US |
dc.relation.ispartof | Blood Coagulation & Fibrinolysis | en_US |
dc.relation.isversionof | 10.1097/00001721-200210000-00005 | en_US |
dc.relation.publicationcategory | Uluslararası Hakemli Dergide Makale - Kurum Öğretim Elemanı | en_US |
dc.rights | CC0 1.0 Universal | * |
dc.rights | info:eu-repo/semantics/openAccess | en_US |
dc.rights.uri | http://creativecommons.org/publicdomain/zero/1.0/ | * |
dc.snmz | KY00433 | |
dc.subject | homocysteine | en_US |
dc.subject | thromboembolic complications | en_US |
dc.subject | atrial fibrilation | en_US |
dc.title | Role of homocysteine for thromboembolic complication in patients with non-valvular atrial fibrilation | en_US |
dc.type | Article | |
dspace.entity.type | Publication |