Distribution of Hepatitis C Virus genotypes in patients with chronic Hepatitis C infection in Eastern Turkey

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dc.authorid0000-0001-5278-0174en_US
dc.contributor.authorOzer, Turkan Toka
dc.contributor.authorBerktas, Mustafa
dc.contributor.authorYaman, Gorkem
dc.contributor.authorErkoc, Reha
dc.date.accessioned2024-07-12T21:45:14Z
dc.date.available2024-07-12T21:45:14Z
dc.date.issued2015en_US
dc.departmentMaltepe Üniversitesien_US
dc.description.abstractViral hepatitis is one of the most important liver diseases in the world. Duration of hepatitis C virus (HCV) infection and response to standard therapy is strongly related to HCV genotypes. Geographical distribution of HCV genotypes is also important for epidemiological studies. We aimed to determine the distribution of HCV genotypes and their prevalence in Eastern Turkey. Fifty eight Anti-HCV, LIA, HCV-RNA positive patients (35 male, 23 female) were included in this study. Genotypes were determined by reverse dot-blot hybridization method. Distribution of HCV genotypes in 58 patients were as follows: Genotype 1b in 53.4% (n=31), genotype 1a in 36.2% (n=21), genotype 1, 3, 4, 1a/1b in 1.7 % (n=1) for each. Genotype 1 was identified as the dominant type in 93.2% (n=54). HCV genotype could not be identified in 3.4% (n=2) patients. Genotype 1b was the most common HCV genotype in our region and this result is in accordance with the previous data of Turkey. Although genotype 1b is predominant, detection of genotype 1a in studies show that genotyping is beneficial for cost-effectiveness of chronic HCV infection. Thus, genotyping of HCV patients in our region guide clinicians in terms of monitoring and treatment success.en_US
dc.description.sponsorshipYuzuncu Yyl University Department of Scientific Research Project [2008-TFI-047]en_US
dc.description.sponsorshipThis study was financially supported by the Yuzuncu Yyl University Department of Scientific Research Project as No. 2008-TFI-047 project. We would like to thank Prof. Dr. Siddik Keskin and Dr. Abdurrahman Ozer, who lent their support to us in the study. This study was presented as oral presentation at 5th EACID 15-18 May 2013, Tirana, Albania.en_US
dc.identifier.endpage701en_US
dc.identifier.issn0970-938X
dc.identifier.issn0976-1683
dc.identifier.issue4en_US
dc.identifier.startpage697en_US
dc.identifier.urihttps://hdl.handle.net/20.500.12415/7814
dc.identifier.volume26en_US
dc.identifier.wosWOS:000364543800017en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Science
dc.language.isoenen_US
dc.publisherALLIED ACADen_US
dc.relation.ispartofBIOMEDICAL RESEARCH-INDIAen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.snmzKY00417
dc.subjectHepatitis C virusen_US
dc.subjectHepatitis C virus genotypesen_US
dc.subjectEastern Turkeyen_US
dc.subjectChronic Hepatitis Cen_US
dc.subjectLIPAen_US
dc.titleDistribution of Hepatitis C Virus genotypes in patients with chronic Hepatitis C infection in Eastern Turkeyen_US
dc.typeArticle
dspace.entity.typePublication

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