False-positivity of mediastinal lymph nodes has negative effect on survival in potentially resectable non-small cell lung cancer

Basit Öğe Kaydı
dc.authorid0000-0001-9169-560Xen_US
dc.contributor.authorİskender, İlker
dc.contributor.authorKadıoğlu, Salih Zeki
dc.contributor.authorCoşgun, Tuğba
dc.contributor.authorKapıcıbaşı, Hasan Oğuz
dc.contributor.authorSağıroğlu, Gönül
dc.contributor.authorKoşar, Altuğ
dc.contributor.authorKir, An
dc.date.accessioned2024-07-12T21:03:36Z
dc.date.available2024-07-12T21:03:36Z
dc.date.issued2012en_US
dc.departmentFakülteler, Tıp Fakültesien_US
dc.description.abstractOBJECTIVES: It has been shown that increased metabolic activity of primary tumour has a negative effect on survival in non-small cell lung cancer (NSCLC) staged with positron emission tomography integrated computed tomography (PET/CT). We hypothesized that an increased metabolic activity of mediastinal lymph nodes would have worse survival even if it is false. METHODS: Three hundred and twenty-eight consecutive patients with NSCLC histology were imaged with PET/CT within 90 days of surgery between September 2005 and March 2009. Patients who had neoadjuvant chemotherapy (n = 22), patients with prior history of NSCLC (n = 9) or other malignancies within 5 years (n = 11) were excluded from the study. Patients with negative mediastinoscopy underwent resection. Pathological results were revised according to the seventh tumor-node-metastasis staging system. Kaplan–Meier test was used for survival. Log-rank and Cox analyses were used for comparisons. RESULTS: A total of 286 patients (262 male; mean age: 58.5 years) were evaluated. There were 22 (6.7%) operative deaths and none of the patients were lost to follow-up. The median follow-up in the remaining 264 patients was 26 months (range, 2–61 months). Tumour size, nodal spread and stage were all strongly associated with survival from NSCLC (P < 0.001). There were 63 true-positive, 65 falsepositive (FP), 152 true-negative (TN) and six false-negative findings on mediastinal staging after PET/CT. The maximum standardized uptake value of primary tumour was significantly higher in FP patients than in TN patients (P = 0.012). After excluding pN2-positive patients, TN patients had better survival than FP patients (P = 0.006). Multivariate analysis showed that false-positivity of mediastinal lymph nodes was independently associated with worse survival (hazard ratio = 0.63; P = 0.02). There were 146 patients with pT1-4, pN0 treated with R0 surgical resection. Disease-free survival and overall survival were also significantly better for TN patients in completely resected group (P = 0.009 versus 0.016). CONCLUSIONS: We have shown that false-positivity of mediastinal lymph nodes had yielded worse survival in surgically staged or resected NSCLC patients staged with PET/CT. This result may help to allocate patients with potentially poor prognosis for considered additional therapy.en_US
dc.identifier.citationİskender, İ., Kadıoğlu, S. Z., Coşgun, T., Kapıcıbaşı, H. O., Sağıroğlu, G., Koşar, A. ve Kir, A. (2012). False-positivity of mediastinal lymph nodes has negative effect on survival in potentially resectable non-small cell lung cancer. European Journal of Cardio-Thoracic Surgery. 41, s. 874-879.en_US
dc.identifier.endpage879en_US
dc.identifier.issue41en_US
dc.identifier.startpage874en_US
dc.identifier.urihttps://pubmed.ncbi.nlm.nih.gov/22423060/
dc.identifier.urihttps://hdl.handle.net/20.500.12415/3682
dc.institutionauthorKoşar, Altuğ
dc.language.isoenen_US
dc.publisherNational Center for Biotechnology Informationen_US
dc.relation.ispartofEuropean Journal of Cardio-Thoracic Surgeryen_US
dc.relation.publicationcategoryUluslararası Hakemli Dergide Makale - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.snmzKY00842
dc.subjectNon-small cell lung canceren_US
dc.subjectPET/CTen_US
dc.subjectMediastinal stagingen_US
dc.subjectFalse-positivityen_US
dc.subjectSurvivalen_US
dc.titleFalse-positivity of mediastinal lymph nodes has negative effect on survival in potentially resectable non-small cell lung canceren_US
dc.typeArticle
dspace.entity.typePublication

Dosyalar

Koleksiyon

Tıp Fakültesi Koleksiyonu