Comparison of Intravesical Application of Chondroitin Sulphate and Colchicine in Rat Protamine/Lipopolysaccharide Induced Cystitis Model

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dc.contributor.authorSinanoglu, Orhun
dc.contributor.authorEkici, Isin Dogan
dc.contributor.authorEkici, Sinan
dc.date.accessioned2024-07-12T21:57:05Z
dc.date.available2024-07-12T21:57:05Z
dc.date.issued2014en_US
dc.departmentMaltepe Üniversitesien_US
dc.description.abstractPurpose: To investigate beneficial effect of the readily available colchicine through its intravesical application on protamine/lipopolysaccharide induced interstitial cystitis model in rat and to compare its efficacy to the chondroitin sulphate available for clinical use. Materials and Methods: Twenty-four Wistar female rats were assigned to control (C), interstitial cystitis (IC), chondroitin sulphate (CS) and colchicine (Col) groups. IC, CS and Col groups received protamine sulphate and lipopolysaccharide (PS/LPS) instillation. Testing agents CS and Col were administered a day after PS/LPS inoculation into the bladders. Rats in Group C received saline solution. CS and Col groups received 1 mL CS (0.2%) and 1 mL Col (0.05 mg/mL). The treatment agents were left in bladders for one hour's duration. Animals were sacrificed 5 days after the inoculation and the bladder tissues were examined histologically to evaluate the amount of extravasated leucocytes, mast cell concentration (by counting total number of cells per 10 high power field (hpf; 1 hpf = x400 magnification) as well as interstitial tissue edema for each bladder. Results: Intravesical application of CS reduced significantly the leucocyte and mast cell infiltration as well as interstitial edema compared to group C. The level of reduction in leucocyte and mast cell infiltration in Col group was comparable to that of CS, although the interstitial edema was not resolved. Conclusion: Intravesical administration of Col decreased leucocyte and mast cell infiltration to the same extent of CS in PS/LPS induced bladder inflammation in rat. Col may be an alternative to other treatment modalities for painful bladder conditions such as IC.en_US
dc.identifier.endpage1300en_US
dc.identifier.issn1735-1308
dc.identifier.issn1735-546X
dc.identifier.issue1en_US
dc.identifier.pmid24595940en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage1296en_US
dc.identifier.urihttps://hdl.handle.net/20.500.12415/8642
dc.identifier.volume11en_US
dc.identifier.wosWOS:000332683000017en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakPubMed
dc.language.isoenen_US
dc.publisherUROL & NEPHROL RES CTR-UNRCen_US
dc.relation.ispartofUROLOGY JOURNALen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.snmzKY03973
dc.subjectcystitisen_US
dc.subjectdisease modelsen_US
dc.subjectanimalen_US
dc.subjectratsen_US
dc.subjectchondroitin sulfatesen_US
dc.subjecttherapeutic use.en_US
dc.titleComparison of Intravesical Application of Chondroitin Sulphate and Colchicine in Rat Protamine/Lipopolysaccharide Induced Cystitis Modelen_US
dc.typeArticle
dspace.entity.typePublication

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