Polymorphisms of the XRCC1 DNA repair gene in head and neck cancer

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dc.authorid0000-0001-7914-2201en_US
dc.contributor.authorDemokan, Semra
dc.contributor.authorDemir, Deniz
dc.contributor.authorSüoğlu, Yusufhan
dc.contributor.authorKıyak, Erkan
dc.contributor.authorAkar, Uğur
dc.contributor.authorDalay, Nejat
dc.contributor.authorDemir, Deniz
dc.date.accessioned2024-07-12T21:01:02Z
dc.date.available2024-07-12T21:01:02Z
dc.date.issued2005en_US
dc.departmentFakülteler, Tıp Fakültesien_US
dc.description.abstractInherited polymorphisms in the genes controlling the cell cycle or functioning in the DNA repair mechanisms may impair their function and contribute to genetic susceptibility. Abnormalities in the DNA repair have been reported in head and neck cancer. The XRCC1 gene functions in singlestrand break and base excision repair processes. In this study, two polymorphisms of the XRCC1 gene, Arg194Trp and Arg399Gln were investigated in 95 patients with head and neck carcinoma. The polymorphic regions were amplified by PCR followed by digestion with methylation-specific restriction enzymes, and analyzed electrophoretically. Genotype and allele frequencies were calculated, and association with cancer risk or clinical parameters was investigated. No association was observed between the genotypes and head and neck cancer for either polymorphism. Distribution of the alleles did not significantly differ between the patients and the control group. A significant association was only found for the Trp194 allele among the smoking individuals. Our data indicate that the Arg194Trp and Arg399Gln polymorphisms do not confer a significant risk for head and neck carcinogenesis.en_US
dc.identifier.citationDemokan, S., Demir, D., Süoğlu, Y., Kıyak, E., Akar, U. ve Dalay, N. (2005). Polymorphisms of the XRCC1 DNA repair gene in head and neck cancer. Pathology oncology research, Arányi Lajos Foundation. 11(1), s. 22-25.en_US
dc.identifier.endpage25en_US
dc.identifier.issn1532-2807
dc.identifier.issue1en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage22en_US
dc.identifier.urihttps://pubmed.ncbi.nlm.nih.gov/15800678/
dc.identifier.urihttps://hdl.handle.net/20.500.12415/3440
dc.identifier.volume11en_US
dc.institutionauthorDemir, Deniz
dc.language.isoenen_US
dc.publisherArányi Lajos Foundationen_US
dc.relation.ispartofPathology oncology researchen_US
dc.relation.isversionof10.1007/BF03032401en_US
dc.relation.publicationcategoryUluslararası Editör Denetimli Dergide Makaleen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.snmzKY03211
dc.subjectpolymorphismen_US
dc.subjectXRCC1en_US
dc.subjecthead and neck canceren_US
dc.titlePolymorphisms of the XRCC1 DNA repair gene in head and neck canceren_US
dc.typeArticle
dspace.entity.typePublication

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