The effects of valsartan on insulin sensitivity in patients with primary hypertension

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dc.authorid0000-0003-2045-1709en_US
dc.authorid0000-0002-8719-8886en_US
dc.contributor.authorTop, C.
dc.contributor.authorTerekeci, Murat Hakan
dc.contributor.authorKüçükardalı, Yaşar
dc.contributor.authorÖnde, Mehmet Emin
dc.contributor.authorDanacı, Mehmet
dc.date.accessioned2024-07-12T21:04:42Z
dc.date.available2024-07-12T21:04:42Z
dc.date.issued2002en_US
dc.departmentFakülteler, Tıp Fakültesien_US
dc.description.abstractInsulin resistance is an important risk factor of cardiovascular disease. This study was performed to determine the effects of valsartan on insulin sensitivity in patients with primary hypertension. In this study, non-obese subjects with primary hypertension and a reference group of healthy subjects matched by age, sex and body mass index were evaluated; patients with any other causes of peripheral insulin resistance and hyperlipidaemia were excluded. The effect of valsartan on insulin resistance, assessed by homeostasis model assessment (HOMA-IR), fasting serum insulin levels, determined by radioimmunoassay, and fasting blood glucose concentrations, measured by the glucose oxidase method, were evaluated. All obtained data were evaluated by Pearson correlation analysis. Before valsartan treatment, the fasting serum insulin levels were significiantly elevated in the 20 hypertensive patients with primary hypertension compared with the 20 subjects in the reference group (19.6 ± 7.1 versus 8.7 ± 1.9 ?IU/ml). The fasting serum insulin levels correlated with HOMA-IR. Correlation analysis also showed a significant relationship between HOMA-IR and both systolic and diastolic blood pressures (r = 0.71 and r = 0.77, respectively). In our study, we showed that patients with primary hypertension have a decreased insulin sensitivity that was reflected in high serum fasting insulin levels. Anti-hypertensive treatment with valsartan increases insulin sensitivity.en_US
dc.identifier.citationTop, C., Cingözbay, B., Terekeci, H., Küçükardali, Y., Önde, M. ve Danaci, M. (2002). The Effects of Valsartan on Insulin Sensitivity in Patients with Primary Hypertension. Journal of International Medical Research, Sage Journals. 15–20.en_US
dc.identifier.endpage20en_US
dc.identifier.issn0300-0605
dc.identifier.issn1473-2300
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage15en_US
dc.identifier.urihttps://journals.sagepub.com/doi/abs/10.1177/147323000203000103#articleCitationDownloadContainer
dc.identifier.urihttps://hdl.handle.net/20.500.12415/3819
dc.institutionauthorCingözbay, Bekir Yılmaz
dc.language.isoenen_US
dc.publisherSage Journalsen_US
dc.relation.ispartofJournal of International Medical Researchen_US
dc.relation.isversionof10.1177/147323000203000103en_US
dc.relation.publicationcategoryUluslararası Hakemli Dergide Makale - Kurum Öğretim Elemanıen_US
dc.rightsCC0 1.0 Universal*
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.rights.urihttp://creativecommons.org/publicdomain/zero/1.0/*
dc.snmzKY01934
dc.subjectValsartanen_US
dc.subjectEssential hypertensionen_US
dc.subjectInsulin sensitivityen_US
dc.titleThe effects of valsartan on insulin sensitivity in patients with primary hypertensionen_US
dc.typeArticle
dspace.entity.typePublication

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