Acute myocardial infarction during thrombolysis of mechanical aortic valve thrombosis associated with heparin-induced thrombocytopenia

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dc.contributor.authorGündüz, Sabahattin
dc.contributor.authorÖzkan, Mehmet
dc.contributor.authorBiteker, Murat
dc.contributor.authorEkşi Duran, Nilüfer
dc.contributor.authorGüneysu, Tahsin
dc.date.accessioned2024-07-12T21:03:00Z
dc.date.available2024-07-12T21:03:00Z
dc.date.issued2011en_US
dc.departmentFakülteler, Tıp Fakültesien_US
dc.description.abstractWe report a case of a 60-year-old man with obstructive aortic prosthetic valve thrombosis (APVT). He was treated with low-dose (25 mg) slow infusion (6 hours) of intravenous tissue plasminogen activator (t-PA), and he suffered acute anterior myocardial infarction (MI) at the fourth hour of t-PA infusion. Infusion was kept on, and coronary reperfusion and successful lysis of APVT were achieved. Intravenous unfractionated heparin (UFH) was then started, however, on the third day following heparin treatment, heparin-induced thrombocytopenia (HIT) was recognized by a drop in the platelet count and rethrombosis of the prosthetic valve. Although no nonheparin anticoagulant was available, intravenous continuous infusion of streptokinase (SKZ) 250,000 U per day was administered for 5 days followed by transition to warfarin therapy. Successful lysis of the APVT was again achieved with this regimen and the patient was discharged after uneventful recovery. The patient remained well at 6 months and 1 year follow-up.en_US
dc.identifier.citationGündüz, S., Özkan, M., Biteker, M., Ekşi Duran, N. ve Güneysu, T. (2011). Acute myocardial infarction during thrombolysis of mechanical aortic valve thrombosis associated with heparin-induced thrombocytopenia. Clinical and Applied Thrombosis/Hemostasis. 17(3), s. 283-287.en_US
dc.identifier.endpage287en_US
dc.identifier.issn1938-2723
dc.identifier.issue3en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage283en_US
dc.identifier.urihttps://hdl.handle.net/20.500.12415/3610
dc.identifier.volume17en_US
dc.institutionauthorEkşi Duran, Nilüfer
dc.language.isoenen_US
dc.publisherNational Library of Medicineen_US
dc.relation.ispartofClinical and Applied Thrombosis/Hemostasisen_US
dc.relation.isversionof10.1177/1076029610363130en_US
dc.relation.publicationcategoryUluslararası Hakemli Dergide Makale - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.snmzKY00520
dc.titleAcute myocardial infarction during thrombolysis of mechanical aortic valve thrombosis associated with heparin-induced thrombocytopeniaen_US
dc.typeArticle
dspace.entity.typePublication

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