The antimicrobial activity of ephedrine and admixture of ephedrine and propofol: an in vitro study

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dc.authorid0000-0003-1996-7505en_US
dc.contributor.authorTulgar, Serkan
dc.contributor.authorAlasehir, Elcin Akduman
dc.contributor.authorSelvi, Onur
dc.date.accessioned2024-07-12T21:53:11Z
dc.date.available2024-07-12T21:53:11Z
dc.date.issued2018en_US
dc.departmentMaltepe Üniversitesien_US
dc.description.abstractIntroduction: Propofol and Ephedrine are commonly used during anesthesia maintenance, the former as a hypnotic agent and the later as a vasopressor. The addition of propofol to ephedrine or administration of ephedrine before propofol injection is useful for decreasing or preventing propofol related hemodynamic changes and vascular pain. This in vitro study evaluated the antibacterial effect on common hospital-acquired infection pathogens of ephedrine alone or combined with propofol. Material and method: The study was performed in two stages. In the first, the Minimum Inhibitory Concentration of propofol and ephedrine alone and combined was calculated for Escherichia coli, Enterococcus faecium, Staphylococcus aureus, Pseudomonas aeruginosa, and a clinical isolate of Acinetobacter spp. at 0, 6, 12 and 24 h, using the microdilution method. In the second stage, the same drugs and combination were used to determine their effect on bacterial growth. Bacterial solutions were prepared at 0.5 MacFarland in sterile 0.9% physiological saline and diluted at 1/100 concentration. Colony numbers were measured as colony forming units. mL(-1) at 0, 2, 4, 6, 8, 10 and 12th hours. Results: Ephedrine either alone or combined with propofol did not have an antimicrobial effect on Escherichia coli, Enterococcus faecium, or Pseudomonas aeruginosa and this was similar to propofol. However, ephedrine alone and combined with propofol was found to have an antimicrobial effect on Staphylococcus aureus and Acinetobacter species at 512 mcg. mL(-1) concentration and significantly decreased bacterial growth rate. Conclusion: Ephedrine has an antimicrobial activity on Staphylococcus aureus and Acinetobacter species which were frequently encountered pathogens as a cause of nosocomial infections. (C) 2017 Sociedade Brasileira de Anestesiologia. Published by Elsevier Editora Ltda.en_US
dc.identifier.doi10.1016/j.bjane.2017.06.004
dc.identifier.endpage74en_US
dc.identifier.issn0034-7094
dc.identifier.issn1806-907X
dc.identifier.issue1en_US
dc.identifier.pmid28870386en_US
dc.identifier.startpage69en_US
dc.identifier.urihttps://dx.doi.org/10.1016/j.bjane.2017.06.004
dc.identifier.urihttps://hdl.handle.net/20.500.12415/8462
dc.identifier.volume68en_US
dc.identifier.wosWOS:000424375300007en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakPubMed
dc.language.isoenen_US
dc.publisherELSEVIER SCIENCE INCen_US
dc.relation.ispartofREVISTA BRASILEIRA DE ANESTESIOLOGIAen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.snmzKY03352
dc.subjectEphedrineen_US
dc.subjectPropofolen_US
dc.subjectAntimicrobialen_US
dc.titleThe antimicrobial activity of ephedrine and admixture of ephedrine and propofol: an in vitro studyen_US
dc.typeArticle
dspace.entity.typePublication

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