The diagnosis of non Hodgkin lymphoma in an epidermodysplasia verruciformis patient

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dc.authorid0000-0002-4075-6692en_US
dc.contributor.authorKaragöz, Bülent
dc.contributor.authorErikçi, Alev Akyol
dc.contributor.authorKarabudak, Özlem
dc.contributor.authorBilgi, Oğuz
dc.contributor.authorSayan, Özkan
dc.contributor.authorKüçükkodaci, Zafer
dc.contributor.authorTürken, Orhan
dc.contributor.authorKandemir, Emin Gökhan
dc.contributor.authorÖztürk, Ahmet Kutlu
dc.date.accessioned2024-07-12T21:46:32Z
dc.date.available2024-07-12T21:46:32Z
dc.date.issued2009en_US
dc.departmentMaltepe Üniversitesien_US
dc.description.abstractEpidermodysplasia verruciformis is a rare, multifactorial disorder. The disease has genetic and immunologic components. Many patients have impaired cell-mediated immunity. Although squamous cell cancers may develop in EV patients, the association with other hematological or solid malignancies and EV is reported in a few studies. In this report, a case of EV with primary mediastinal large B-cell lymphoma is presented. A 20-year-old man with a five years history of red-brown macular lesions was admitted to our hospital. The skin biopsy revealed epidermodysplasia verruciformis. Persistent cough started during the hospitalization. On the chest X-ray, mediastinal enlargement was determined. Thoracic computed tomography demonstrated a mediastinal mass of 6 cm in diameter. Diffuse, large B-cell lymphoma was diagnosed. The chemotherapy (R-CHOP regiment) and involved field radiotherapy were administered. Complete response was achieved after the combined treatment modality. He is lymphoma-free for 18 months follow-up. Epidermodysplasia verruciformis is frequently seen in immunosuppressive patients and many accompany infections with type human papilloma virus subtypes such as 5 and 8. These human papilloma virus subtypes that have oncogenic properties may trigger lymphomagenesis. In addition, lymphomas are seen more frequently in immunosuppressive patients than healthy persons. We conclude that there may be a predisposition to lymphoma development in epidermodysplasia verruciformis patients.en_US
dc.identifier.endpage85en_US
dc.identifier.issn1304-3889
dc.identifier.issue2en_US
dc.identifier.scopus2-s2.0-67650497333en_US
dc.identifier.scopusqualityN/Aen_US
dc.identifier.startpage83en_US
dc.identifier.urihttps://hdl.handle.net/20.500.12415/7942
dc.identifier.volume6en_US
dc.indekslendigikaynakScopus
dc.language.isoenen_US
dc.relation.ispartofEuropean Journal of General Medicineen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.snmzKY00849
dc.subjectEpidermodysplasia verruciformisen_US
dc.subjectHuman papilloma virusen_US
dc.subjectImmunosuppressionen_US
dc.subjectNon-Hodgkin's lymphomaen_US
dc.titleThe diagnosis of non Hodgkin lymphoma in an epidermodysplasia verruciformis patienten_US
dc.typeArticle
dspace.entity.typePublication

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